BSG Specific Recomb™ Antibody (V3S-0923-CJ3), Mouse IgG (CAT#: V3S-0923-CJ3)

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Virus Background


Description This mouse anti-BSG mAb (clone M6-1B9) recognizes human BSC (CD147). M6-1B9 recognizes both native (glycosylated) and recombinant (non-glycosylated) CD147 molecules.
Clonality Monoclonal
Host Species Mouse
Target Species Human
Immunogen Recombinant CD147-biotin carboxyl carrier protein (BCCP)
ED50 3.81 mg/kg
Function Isoform 1:
Essential for normal retinal maturation and development.
Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed: 25957687).
In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed: 25957687).
May act as a potent stimulator of IL6 secretion in multiple cell lines that include monocytes (PubMed: 21620857).

Isoform 2
Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (PubMed: 11943775, PubMed: 11688976).
Plays an important role in targeting monocarboxylate transporters SLC16A1/GLUT1, SLC16A11 and SLC16A12 to the plasma membrane (PubMed: 17127621, PubMed: 21778275, PubMed: 28666119).
Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (PubMed: 25825981).
Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA (isoform VEGF-165 and VEGF-121) and KDR/VEGFR2 in endothelial cells (PubMed: 19837976).
Plays a key role in regulating tumor growth, invasion, metastasis and neoangiogenesis by stimulating the production and release of extracellular matrix metalloproteinases and KDR/VEGFR2 by both tumor cells and stromal cells (fibroblasts and endothelial cells) (PubMed: 12553375, PubMed: 11992541, PubMed: 15833850).
Isotype Mouse IgG


Expression Species HEK293F or CHO cell line
Conjugation Unconjugated
Purity >95%
Endotoxin <1 EU/mg
Form Liquid
Purification Protein G purified
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4°C within a week. For longer storage, aliquot and store at -20°C.


Application ELISA; WB; FC; ICC
Application Notes The specificity of scFv M6-1B9 toward CD147 was analyzed by indirect ELISA using a recombinant CD147-BCCP as a target. The result of Western Blotting showed the expression of Fab M6-1B9 and scFv M6-1B9 on phage particles. The scFv M6-1B9 has been tested in use for Flow Cytometry on U937 and 293A cells. The colocalization of scFv-M6-1B9 intrabody and CD147 was analyzed by Immunocytochemical analysis in transfected 293A cells.


ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol


Target BSG
Alternative Name OK; 5F7; TCSF; CD147; EMPRIN; HAb18G; EMMPRIN
Gene ID 682
UniProt P35613
Research Area Epigenetics
Related Disease Tumors

Virus Background

Post Translational Modification Isoform 2: N-glycosylated.
Isoform 3: N-glycosylated.
Isoform 4: N-glycosylated.
For research use only, not directly for clinical use.
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