| Description | This is an inhibitory monoclonal antibody that recognize human IL18RAP. IgG 3131 inhibited IFN-gamma secretion in a dose-dependent manner. It also prevented the formation of the ternary signaling complex by inhibiting the binding of soluble IL-18/IL-18Ra to immobilized IL-18Rb, as confirmed by ELISA. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| IC50 | 3 ± 2 nM (KG1 cell) 4 ± 2 nM (PBMC) |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Inhib; FC; IF |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | IL18RAP |
| Alternative Name | ACPL; CD218b; IL-1R7; IL18RB; CDw218b; IL-1R-7; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta; interleukin-18 receptor accessory protein; CD218 antigen-like family member B; IL-18 receptor accessory protein; IL-18 receptor beta; cluster of differentiation w218b; interleukin-1 receptor 7; interleukin-18 receptor beta |
| Gene ID | 8807 |
| UniProt | O95256 |
| Research Area | Immunology; Cancer Research; Autophagy |
