| Description | mAb7 exhibited high affinity for human PD-1 and cynomolgus monkey-PD-1, displaying similar EC50 values across the two species. The anti-PD-1 antibodies, mAb7 and C1, bind to activated T cells with comparable EC50. mAb7 inhibites PD-1 signaling and enhances the secretion of IFNy and TNF from primary human T cells. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human, Cynomolgus |
| Cross Reactivity | This antibody has weakly cross reactive with mouse PD1. |
| Isotype | IgG4 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein G purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISPOT; ICC; FuncS |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
