PDCD1 Specific Neutra™ Antibody Products

Product list

Programmed cell death protein 1 (PDCD1), also named as PD-1 or CD279, is a protein expressed in immune cells such as T cells, B cells and NK cells. PD-1 is an immune checkpoint protein involved in apoptosis of T cells. As a drug target, the inhibitors against PD-1 can attack tumors by blocking PD-1 interaction via activating the immune system.

Function

As an inhibitor, PD-1 plays an important role in the immune system, including down-regulating the immune responses and promoting self-tolerance. Here are some functions that PD-1 may involve in.

Regulate T-cell functions.
Promotes the function and development of Tregs.
Inhibits the function of cytotoxic T lymphocytes.
Protect against autoimmunity.
Reduce antimicrobial immunity.
Attenuate antitumor immunity.

Signaling pathways targeted by PD-1

The ligands of PD-1 are mainly known as PD-L1 and PD-L2. PD-1 with its ligands are involved in a number of signaling pathways to exert immunosuppressive functions in T cells.

PD-1:PD-L1 pathway
PI3K/AKT pathway
Mitogen-activated protein kinase (MAPK) pathway
Mammalian target of rapamycin (mTOR) pathway

Clinical significance of PD-1

PD-L1 is highly expressed in several cancers and blockade of PD-1/PD-L1 interaction can enhance T-cell responses and mediate preclinical antitumor activity. Therefore, PD-1 is a promising target for immunotherapies and anti-PD-1 blocking antibodies are being developed for immunotherapies of cancer and chronic infections.

Treatment/targets	Mechanism of action	Outcome in T cells
Inhibition of PD-1 core fucosylation	Decreased surface expression of PD-1 on T cells	Increased T cell function
Enhancing expression of ubiquitin ligase FBXO38	Increased PD-1 degradation in T cells	Increased T cell function
EGFR inhibitors + PD-1 blockade	Decreased PD-L1 expression	Increased T cell function
CSN5 inhibitors (or curcumin) + CTLA-4 blockade	Decreased PD-L1 expression	Increased T cell function
CMTM4/6 degradation	Decreased PD-L1 expression	Increased T cell function
Antibodies against glycosylated PD-L1	PD-L1 internalization and degradation	Increased T cell function

Table 1 Candidate immunotherapy by targeting the PD-1 pathway.¹

Creative Biolabs offers a comprehensive range of anti-PDCD1 antibodies. These antibodies were recombinant expression and performed quality control with commercial PD-1 antigen.

Fig. 1 Human PD-1 protein was serially diluted and probed with anti-PDCD1 antibody (V3S-0622-YC2365) in WB.

Fig. 2 PD-1 protein was detected in ELISA using anti-PDCD1 antibody (V3S-0622-YC2365).

Fig. 3 Dot blot analysis of anti-PDCD1 antibody (V3S-0622-YC2365) with human PD-1 antigen.

REFERENCE

Patsoukis, N.; et al. Revisiting the PD-1 pathway. Science advances. 2020, 6(38): eabd2712.

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Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2362) (CAT#: V3S-0622-YC2362)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: WB,DB,ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2365) (CAT#: V3S-0622-YC2365)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,WB,DB,FC,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC5183) (CAT#: V3S-0622-YC5183)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: WB,IF,IP,Neut,FuncS,ELISA,FC,ICC,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC1439) (CAT#: V3S-0522-YC1439)

Target: PDCD1

Host Species: Canine

Target Species: Dog,

Application: WB,DB,ELISA,IHC,FC,IP,IF,FuncS,

Anti-PDCD1 (aa 25-170) Neutralizing Antibody (V3S-0622-YC424) (CAT#: V3S-0622-YC424)

Target: PDCD1

Host Species: Human

Target Species: Human, Cynomolgus,

Application: SPR,Neut,FC,FuncS,

Anti-PDCD1 (aa 25-170) Neutralizing Antibody (V3S-0622-YC425) (CAT#: V3S-0622-YC425)

Target: PDCD1

Host Species: Human

Target Species: Human, Cynomolgus,

Application: Block,SPR,FC,FuncS,

Anti-PDCD1 (aa 25-170) Neutralizing Antibody (V3S-0622-YC426) (CAT#: V3S-0622-YC426)

Target: PDCD1

Host Species: Human

Target Species: Human, Cynomolgus,

Application: Block,SPR,FC,FuncS,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC427) (CAT#: V3S-0622-YC427)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FC,Block,FuncS,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2349) (CAT#: V3S-0622-YC2349)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2350) (CAT#: V3S-0622-YC2350)

Target: PDCD1

Host Species: Human

Target Species: Mouse,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2351) (CAT#: V3S-0622-YC2351)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0622-YC2352) (CAT#: V3S-0622-YC2352)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0622-YC2353) (CAT#: V3S-0622-YC2353)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2354) (CAT#: V3S-0622-YC2354)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2355) (CAT#: V3S-0622-YC2355)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,WB,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2356) (CAT#: V3S-0622-YC2356)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,WB,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2357) (CAT#: V3S-0622-YC2357)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2358) (CAT#: V3S-0622-YC2358)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2359) (CAT#: V3S-0622-YC2359)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2360) (CAT#: V3S-0622-YC2360)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2361) (CAT#: V3S-0622-YC2361)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2363) (CAT#: V3S-0622-YC2363)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2364) (CAT#: V3S-0622-YC2364)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2366) (CAT#: V3S-0622-YC2366)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2367) (CAT#: V3S-0622-YC2367)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2368) (CAT#: V3S-0622-YC2368)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2369) (CAT#: V3S-0622-YC2369)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3763) (CAT#: V3S-0622-YC3763)

Target: PDCD1

Host Species: Human

Target Species: Human, Monkey,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3764) (CAT#: V3S-0622-YC3764)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3765) (CAT#: V3S-0622-YC3765)

Target: PDCD1

Host Species: Rat

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3766) (CAT#: V3S-0622-YC3766)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3767) (CAT#: V3S-0622-YC3767)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3768) (CAT#: V3S-0622-YC3768)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3769) (CAT#: V3S-0622-YC3769)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,FC,IHC,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC3770) (CAT#: V3S-0622-YC3770)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,Inhib,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3771) (CAT#: V3S-0622-YC3771)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,WB,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC5182) (CAT#: V3S-0622-YC5182)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: FuncS,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC5184) (CAT#: V3S-0622-YC5184)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: IP,IF,FuncS,FC,Neut,ELISA,ICC,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC1396) (CAT#: V3S-0522-YC1396)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC1423) (CAT#: V3S-0522-YC1423)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,FC,IP,IF,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2495) (CAT#: V3S-0522-YC2495)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: FC,Block,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2509) (CAT#: V3S-0522-YC2509)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Recombinant Anti-PDCD1 (aa 1-167) Antibody (V3S-0522-YC2510) (CAT#: V3S-0522-YC2510)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2511) (CAT#: V3S-0522-YC2511)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2512) (CAT#: V3S-0522-YC2512)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FuncS,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0522-YC2513) (CAT#: V3S-0522-YC2513)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2514) (CAT#: V3S-0522-YC2514)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,FC,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2515) (CAT#: V3S-0522-YC2515)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2516) (CAT#: V3S-0522-YC2516)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,Block,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2517) (CAT#: V3S-0522-YC2517)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,IHC,

For research use only, not directly for clinical use.

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