PDCD1 Specific Neutra™ Antibody Products

Product list

Programmed cell death protein 1 (PDCD1), also named as PD-1 or CD279, is a protein expressed in immune cells such as T cells, B cells and NK cells. PD-1 is an immune checkpoint protein involved in apoptosis of T cells. As a drug target, the inhibitors against PD-1 can attack tumors by blocking PD-1 interaction via activating the immune system.

Function

As an inhibitor, PD-1 plays an important role in the immune system, including down-regulating the immune responses and promoting self-tolerance. Here are some functions that PD-1 may involve in.

Regulate T-cell functions.
Promotes the function and development of Tregs.
Inhibits the function of cytotoxic T lymphocytes.
Protect against autoimmunity.
Reduce antimicrobial immunity.
Attenuate antitumor immunity.

Signaling pathways targeted by PD-1

The ligands of PD-1 are mainly known as PD-L1 and PD-L2. PD-1 with its ligands are involved in a number of signaling pathways to exert immunosuppressive functions in T cells.

PD-1:PD-L1 pathway
PI3K/AKT pathway
Mitogen-activated protein kinase (MAPK) pathway
Mammalian target of rapamycin (mTOR) pathway

Clinical significance of PD-1

PD-L1 is highly expressed in several cancers and blockade of PD-1/PD-L1 interaction can enhance T-cell responses and mediate preclinical antitumor activity. Therefore, PD-1 is a promising target for immunotherapies and anti-PD-1 blocking antibodies are being developed for immunotherapies of cancer and chronic infections.

Treatment/targets	Mechanism of action	Outcome in T cells
Inhibition of PD-1 core fucosylation	Decreased surface expression of PD-1 on T cells	Increased T cell function
Enhancing expression of ubiquitin ligase FBXO38	Increased PD-1 degradation in T cells	Increased T cell function
EGFR inhibitors + PD-1 blockade	Decreased PD-L1 expression	Increased T cell function
CSN5 inhibitors (or curcumin) + CTLA-4 blockade	Decreased PD-L1 expression	Increased T cell function
CMTM4/6 degradation	Decreased PD-L1 expression	Increased T cell function
Antibodies against glycosylated PD-L1	PD-L1 internalization and degradation	Increased T cell function

Table 1 Candidate immunotherapy by targeting the PD-1 pathway.¹

Creative Biolabs offers a comprehensive range of anti-PDCD1 antibodies. These antibodies were recombinant expression and performed quality control with commercial PD-1 antigen.

Fig. 1 Human PD-1 protein was serially diluted and probed with anti-PDCD1 antibody (V3S-0622-YC2365) in WB.

Fig. 2 PD-1 protein was detected in ELISA using anti-PDCD1 antibody (V3S-0622-YC2365).

Fig. 3 Dot blot analysis of anti-PDCD1 antibody (V3S-0622-YC2365) with human PD-1 antigen.

REFERENCE

Patsoukis, N.; et al. Revisiting the PD-1 pathway. Science advances. 2020, 6(38): eabd2712.

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Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2362) (CAT#: V3S-0622-YC2362)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: WB,DB,ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2365) (CAT#: V3S-0622-YC2365)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,WB,DB,FC,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC5183) (CAT#: V3S-0622-YC5183)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: WB,IF,IP,Neut,FuncS,ELISA,FC,ICC,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC1439) (CAT#: V3S-0522-YC1439)

Target: PDCD1

Host Species: Canine

Target Species: Dog,

Application: WB,DB,ELISA,IHC,FC,IP,IF,FuncS,

Anti-PDCD1 (aa 25-170) Neutralizing Antibody (V3S-0622-YC424) (CAT#: V3S-0622-YC424)

Target: PDCD1

Host Species: Human

Target Species: Human, Cynomolgus,

Application: SPR,Neut,FC,FuncS,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2350) (CAT#: V3S-0622-YC2350)

Target: PDCD1

Host Species: Human

Target Species: Mouse,

Application: ELISA,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0622-YC2352) (CAT#: V3S-0622-YC2352)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0622-YC2353) (CAT#: V3S-0622-YC2353)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2354) (CAT#: V3S-0622-YC2354)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2357) (CAT#: V3S-0622-YC2357)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2359) (CAT#: V3S-0622-YC2359)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2360) (CAT#: V3S-0622-YC2360)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2361) (CAT#: V3S-0622-YC2361)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2363) (CAT#: V3S-0622-YC2363)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2366) (CAT#: V3S-0622-YC2366)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2367) (CAT#: V3S-0622-YC2367)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2368) (CAT#: V3S-0622-YC2368)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC2369) (CAT#: V3S-0622-YC2369)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Recombinant Rat Anti-PDCD1 Antibody (V3S-0622-YC3765) (CAT#: V3S-0622-YC3765)

Target: PDCD1

Host Species: Rat

Target Species: Human,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-0622-YC3769) (CAT#: V3S-0622-YC3769)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,FC,IHC,

Anti-PDCD1 Neutralizing Antibody (V3S-0622-YC5182) (CAT#: V3S-0622-YC5182)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: FuncS,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC1423) (CAT#: V3S-0522-YC1423)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,FC,IP,IF,Block,

Recombinant Anti-PDCD1 (aa 1-167) Antibody (V3S-0522-YC2510) (CAT#: V3S-0522-YC2510)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0522-YC2513) (CAT#: V3S-0522-YC2513)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2514) (CAT#: V3S-0522-YC2514)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,FC,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2515) (CAT#: V3S-0522-YC2515)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2516) (CAT#: V3S-0522-YC2516)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2520) (CAT#: V3S-0522-YC2520)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2526) (CAT#: V3S-0522-YC2526)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FC,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2527) (CAT#: V3S-0522-YC2527)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FC,Block,

Human Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2532) (CAT#: V3S-0522-YC2532)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: ELISA,FC,Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2538) (CAT#: V3S-0522-YC2538)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISpot,Block,

Mouse Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2541) (CAT#: V3S-0522-YC2541)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: ELISA,FuncS,Block,

Recombinant Anti-PDCD1 (ECD domain) Antibody (V3S-0522-YC2688) (CAT#: V3S-0522-YC2688)

Target: PDCD1

Host Species: Mouse

Target Species: Human, Cynomolgus,

Application: ELISA,FC,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2690) (CAT#: V3S-0522-YC2690)

Target: PDCD1

Host Species: Human

Target Species: Human, Cynomolgus,

Application: FC,FuncS,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC2692) (CAT#: V3S-0522-YC2692)

Target: PDCD1

Host Species: Human

Target Species: Human, Cynomolgus,

Application: FC,Neut,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2725) (CAT#: V3S-0522-YC2725)

Target: PDCD1

Host Species: Human

Target Species: Human, Monkey,

Application: FC,FuncS,

Recombinant Anti-PDCD1 Antibody (V3S-0522-YC2757) (CAT#: V3S-0522-YC2757)

Target: PDCD1

Host Species: Human

Target Species: Human, Mouse, Cynomolgus,

Application: ELISA,FC,FuncS,

Anti-PDCD1 Neutralizing Antibody (V3S-0522-YC7039) (CAT#: V3S-0522-YC7039)

Target: PDCD1

Host Species: Human

Target Species: Human, Mouse,

Application: Block,

Clone MO63042, Anti-Canine PDCD1 Monoclonal Antibody (CAT#: F70330)

Target: PDCD1

Host Species: Canine

Target Species: Canine,

Application: ELISA,IHC,IF,IP,FC,FuncS,

Anti-Pdcd1 Neutralizing Antibody (V3S-0822-YC2192) (CAT#: V3S-0822-YC2192)

Target: Pdcd1

Host Species: Rat

Target Species: Mouse,

Application: Block,IHC,FC,

Anti-Pdcd1 Neutralizing Antibody (V3S-0822-YC2193) (CAT#: V3S-0822-YC2193)

Target: Pdcd1

Host Species: Hamster

Target Species: Mouse,

Application: Block,WB,

Anti-PDCD1 Neutralizing Antibody (V3S-0822-YC2197) (CAT#: V3S-0822-YC2197)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: Neut,WB,

Anti-Pdcd1 Neutralizing Antibody (V3S-0822-YC2768) (CAT#: V3S-0822-YC2768)

Target: Pdcd1

Host Species: Rat

Target Species: Mouse,

Application: Block,

Anti-PDCD1 Neutralizing Antibody (V3S-0822-YC2769) (CAT#: V3S-0822-YC2769)

Target: PDCD1

Host Species: Mouse

Target Species: Human,

Application: Neut,

Anti-PDCD1 Neutralizing Antibody (V3S-1022-YC1353) (CAT#: V3S-1022-YC1353)

Target: PDCD1

Host Species: Human

Target Species: Human,

Application: Block,

Recombinant Anti-PDCD1 Antibody (V3S-1022-YC1793) (CAT#: V3S-1022-YC1793)

Target: PDCD1

Host Species: Mouse

Target Species: Rhesus,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-1022-YC1794) (CAT#: V3S-1022-YC1794)

Target: PDCD1

Host Species: Mouse

Target Species: Rhesus,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-1022-YC1795) (CAT#: V3S-1022-YC1795)

Target: PDCD1

Host Species: Mouse

Target Species: Rhesus,

Application: ELISA,

Recombinant Anti-PDCD1 Antibody (V3S-1022-YC1796) (CAT#: V3S-1022-YC1796)

Target: PDCD1

Host Species: Mouse

Target Species: Rhesus,

Application: ELISA,

For research use only, not directly for clinical use.

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