| Description | PD1AB-6-IgG1 effectively binds to human PD-1 expressed on CHO cells, exhibiting an EC50 of 0.4 nM. Additionally, it also binds to Cyno PD-1 expressed on CHO cells with an EC50 of 0.8 nM. The rates of association and dissociation of PD1AB-6-IgG1 to the PD-1 antigen are comparable, as indicated by the KD values of 20 nM. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Cynomolgus |
| Affinity | 20 nM |
| Isotype | IgG1 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ADCC; CDC |
| Application Notes | PD1AB-6-IgG1 effectively binds to human PD-1 expressed on CHO cells with an EC50 of 0.4 nM and Cyno PD-1 expressed on CHO cells with an EC50 of 0.8 nM. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
