| Description | This is an inhibitory monoclonal antibody that recognizes human SERPINE1. It has a strong affinity and specificity for the active form of human PAI-1. The antibody effectively inhibits serine protease interactions with PAI-1, while also preserving vitronectin binding. The antibody is effective in mouse models of diabetic nephropathy. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Rat |
| IC50 | 10.5 nM (Human) 1.3 nM (Mouse) |
| Affinity | KD = 6 pM (human) KD = 105 pM (rat) |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Inhib; FuncS |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | SERPINE1 |
| Alternative Name | SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI; PAI1; PAI-1; PLANH1; plasminogen activator inhibitor 1; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| Gene ID | 5054 |
| UniProt | P05121 |
| Research Area | Cardiovascular |
