CD28 Specific NeutraTM Antibody Products

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CD28 molecule (CD28), also known as TP44, is a single-pass membrane glycoprotein overexpressed in CD8+ T cells and CD4+ T cells. CD28 reacts with the co-stimulatory ligands B7-1 and B7-2 on antigen-presenting cells. CD28 is essential for the regulation of T cell immune responses.

Its Gene ID: 940, UniProtKB ID: P10747, and OMIM ID: 186760.

Mechanisms

CD28 plays an important role in T-cell activation and cytokine production. T cells are activated by the binding of CD28 to B7-1/B7-2 when TCRs bind to cognate antigens. Activated T cells begin to display CTLA4 or PD1 on the cell surface. CTLA4 then binds to B7-1 and B7-2 molecules instead of CD28, while PD1 binds to PDL1/2 on APCs, promoting anergy and exhaustion in lymphoid and peripheral tissues, respectively. The B7/CD28 pathway could be applied to regulate immune responses.

Fig.1 Mechanisms of T cell activation and regulation with CD28. (Waldman, et al., 2020)Fig.1 Mechanisms of T cell activation and regulation with CD28.1

Clinical Significance of CD28

There is a correlation between the expression of CD28 and the degree of malignancy development in patients with lung cancer and organ transplantation. CD28 expression in primary tumor tissue was significantly different from normal tissue and is associated with earlier TNM stage and fewer lymph node metastases. It is proposed as a detection target for the prognosis of cancer treatment response.

Fig.2 The role of CD28 in the prognosis of lung cancer. (Sun, et al., 2020)Fig.2 The role of CD28 in the prognosis of lung cancer.2

REFERENCES

  1. Waldman, Alex D., Jill M. Fritz, and Michael J. Lenardo. "A guide to cancer immunotherapy: from T cell basic science to clinical practice." Nature Reviews Immunology 20.11 (2020): 651-668.
  2. Sun, Dantong, et al. "The role of CD28 in the prognosis of young lung adenocarcinoma patients." Bmc Cancer 20 (2020): 1-11.
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Recombinant Anti-CD28 Antibody (V3S-0522-YC5196) (CAT#: V3S-0522-YC5196)

Target: CD28

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Recombinant Anti-CD28 Antibody (V3S-0622-YC2974) (CAT#: V3S-0622-YC2974)

Target: CD28

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

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Anti-CD28 Neutralizing Antibody (V3S-0622-YC4316) (CAT#: V3S-0622-YC4316)

Target: CD28

Host Species: Human

Target Species: Human,

Application: IP,IF,FuncS,FC,Neut,ELISA,IHC,

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Anti-CD28 Neutralizing Antibody (V3S-0522-YC505) (CAT#: V3S-0522-YC505)

Target: CD28

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,Block,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC5197) (CAT#: V3S-0522-YC5197)

Target: CD28

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC5198) (CAT#: V3S-0522-YC5198)

Target: CD28

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC5199) (CAT#: V3S-0522-YC5199)

Target: CD28

Host Species: Mouse

Target Species: Human,

Application: ELISA,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC5200) (CAT#: V3S-0522-YC5200)

Target: CD28

Host Species: Human

Target Species: Human,

Application: FC,ELISA,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC5201) (CAT#: V3S-0522-YC5201)

Target: CD28

Host Species: Human

Target Species: Human,

Application: FC,ELISA,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC7598) (CAT#: V3S-0522-YC7598)

Target: CD28

Host Species: Mouse

Target Species: Dog,

Application: WB,ELISA,FuncS,

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Recombinant Anti-CD28 Antibody (V3S-0522-YC8085) (CAT#: V3S-0522-YC8085)

Target: CD28

Host Species: Mouse

Target Species: Human,

Application: WB,ELISA,FuncS,

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Clone MO24604, Anti-Chicken CD28 Monoclonal Antibody (CAT#: F42726)

Target: CD28

Host Species: Mouse

Target Species: Chicken, Turkey,

Application: FC,

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Clone MO16665, Anti-Rat CD28 Monoclonal Antibody (CAT#: F12622)

Target: Cd28

Host Species: Mouse

Target Species: Rat,

Application: Costim,Agonist,FC,IF,IHC,FuncS,

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Clone MO66572, Anti-Rat CD28 Monoclonal Antibody (CAT#: F40001)

Target: Cd28

Host Species: Mouse

Target Species: Rat,

Application: IP,FC,

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Clone MO70442, Anti-canine CD28 Monoclonal Antibody (CAT#: F66302)

Target: CD28

Host Species: Mouse

Target Species: canine,

Application: WB,ELISA,FuncS,

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Anti-CD28 Neutralizing Antibody (V3S-0822-YC697) (CAT#: V3S-0822-YC697)

Target: CD28

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,Neut,WB,

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Anti-Cd28 Neutralizing Antibody (V3S-0822-YC698) (CAT#: V3S-0822-YC698)

Target: Cd28

Host Species: Hamster

Target Species: Mouse,

Application: IHC-Fr,FC,IP,Block,FA,

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Anti-Cd28 Neutralizing Antibody (V3S-0822-YC699) (CAT#: V3S-0822-YC699)

Target: Cd28

Host Species: Mouse

Target Species: Mouse,

Application: FC,Costim,Block,

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Anti-Cd28 Neutralizing Antibody (V3S-0822-YC700) (CAT#: V3S-0822-YC700)

Target: Cd28

Host Species: Hamster

Target Species: Mouse,

Application: Neut,

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Recombinant Anti-CD28 Antibody (V3S-0822-YC2670) (CAT#: V3S-0822-YC2670)

Target: CD28

Host Species: Mouse

Target Species: Human, Monkey,

Application: Stim,Activ,FC,IHC-Fr,

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Recombinant Anti-CD28 Antibody (V3S-0822-YC2671) (CAT#: V3S-0822-YC2671)

Target: CD28

Host Species: Mouse

Target Species: Human,

Application: Stim,Activ,

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Recombinant Anti-Cd28 Antibody (V3S-0822-YC2672) (CAT#: V3S-0822-YC2672)

Target: Cd28

Host Species: Mouse

Target Species: Rat,

Application: Stim,Activ,FC,

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Recombinant Anti-Cd28 Antibody (V3S-0822-YC2673) (CAT#: V3S-0822-YC2673)

Target: Cd28

Host Species: Mouse

Target Species: Mouse,

Application: Stim,Activ,

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Anti-Cd28 Neutralizing Antibody (V3S-0822-YC2674) (CAT#: V3S-0822-YC2674)

Target: Cd28

Host Species: Hamster

Target Species: Mouse,

Application: Stim,Activ,Block,

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Recombinant Anti-Cd28 Antibody (V3S-0822-YC2675) (CAT#: V3S-0822-YC2675)

Target: Cd28

Host Species: Hamster

Target Species: Mouse,

Application: Stim,Activ,

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Recombinant Anti-CD28 Antibody (V3S-1022-YC158) (CAT#: V3S-1022-YC158)

Target: CD28

Host Species: Mouse

Target Species: Human,

Application: WB,IP,IF,FC,

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Recombinant Anti-CD28 Antibody (V3S-1022-YC159) (CAT#: V3S-1022-YC159)

Target: CD28

Host Species: Mouse

Target Species: Human,

Application: FC,FuncS,ICC,IHC,IP,WB,

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Recombinant Anti-CD28 Antibody (V3S-1022-YC1258) (CAT#: V3S-1022-YC1258)

Target: CD28

Host Species: Human

Target Species: Human,

Application: WB,ELISA,

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Recombinant Anti-CD28 Antibody (V3S-1022-YC2271) (CAT#: V3S-1022-YC2271)

Target: CD28

Host Species: Human

Target Species: Human, Rat,

Application: WB,ELISA,

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Recombinant Anti-CD28 Antibody (V3S-1022-YC2697) (CAT#: V3S-1022-YC2697)

Target: CD28

Host Species: Mouse

Target Species: Chicken, Turkey,

Application: FC,

For research use only, not directly for clinical use.


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