Cluster of differentiation 3 (CD3) is a surface structure consisting of four polypeptide chains: δ, ε, γ, and ζ. The multimeric CD3 molecules are involved in the TCR complex assembly, T cell activation, and antigen recognition. The CD3 molecule is a promising target for immunodeficiency disorders and cancer immunotherapy.
The CD3 molecule associates with the TCR via non-covalent hydrophobic interactions and it stabilizes the complete TCR localization on the cell surface. After TCR binds to the MHC-peptide complex, various enzymes and adaptors are activated, and a series of signaling pathways are transducted, as shown in Figure 1.
Fig.1 CD3 involved in the positive regulation of T cell signaling.1
The strategies listed below could rescue and boost T cell activity and potentiate the antitumor efficacy.
A variety of CD3 modulators are currently being investigated as desirable drug candidates, such as anti-CD3 monoclonal antibodies, CD3 T cell engagers, and CD3 specific DNA/RNA aptamers.
Tab. 1 CD3 modulators in preclinical and clinical studies.2
Creative Biolabs offers more than one hundred anti-CD3 antibody products with sixteen applications including ELISA, inhibition, and stimulation assays. These anti-CD3 antibodies were well-developed with stringent quality controls and could be used in the therapeutic research as our customers desired.
Recombinant Anti-CD3 Antibody (V3S-0522-YC6987) (CAT#: V3S-0522-YC6987)
Target: CD3
Host Species: Human
Target Species: Human,
Application: WB,FC,
Anti-CD3 Neutralizing Antibody (V3S-0622-YC1278) (CAT#: V3S-0622-YC1278)
Target: CD3
Host Species: Rat
Target Species: Mouse,
Application: FuncS,
Anti-CD3 Neutralizing Antibody (V3S-0622-YC1279) (CAT#: V3S-0622-YC1279)
Target: CD3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-CD3 Neutralizing Antibody (V3S-0622-YC1280) (CAT#: V3S-0622-YC1280)
Target: CD3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-CD3 Neutralizing Antibody (V3S-0622-YC1281) (CAT#: V3S-0622-YC1281)
Target: CD3
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Recombinant Anti-CD3 Antibody (V3S-0622-YC1284) (CAT#: V3S-0622-YC1284)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC1285) (CAT#: V3S-0622-YC1285)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC1286) (CAT#: V3S-0622-YC1286)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC1287) (CAT#: V3S-0622-YC1287)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,SPR,
Recombinant Anti-CD3 Antibody (V3S-0622-YC1288) (CAT#: V3S-0622-YC1288)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,SPR,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2975) (CAT#: V3S-0622-YC2975)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2979) (CAT#: V3S-0622-YC2979)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2980) (CAT#: V3S-0622-YC2980)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2981) (CAT#: V3S-0622-YC2981)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2982) (CAT#: V3S-0622-YC2982)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2983) (CAT#: V3S-0622-YC2983)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2984) (CAT#: V3S-0622-YC2984)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2985) (CAT#: V3S-0622-YC2985)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2986) (CAT#: V3S-0622-YC2986)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2987) (CAT#: V3S-0622-YC2987)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0622-YC2988) (CAT#: V3S-0622-YC2988)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC40) (CAT#: V3S-0522-YC40)
Target: CD3
Host Species: Mouse
Target Species: Pig,
Application: FuncS,
Recombinant Anti-CD3 Antibody (V3S-0522-YC41) (CAT#: V3S-0522-YC41)
Target: CD3
Host Species: Mouse
Target Species: Monkey,
Application: WB,FC,FuncS,
Recombinant Anti-CD3 Antibody (V3S-0522-YC3153) (CAT#: V3S-0522-YC3153)
Target: CD3
Host Species: Mouse
Target Species: Human,
Application: FC,IHC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC3154) (CAT#: V3S-0522-YC3154)
Target: CD3
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC3156) (CAT#: V3S-0522-YC3156)
Target: CD3
Host Species: Hamster
Target Species: Mouse,
Application: FuncS,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5202) (CAT#: V3S-0522-YC5202)
Target: CD3
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5203) (CAT#: V3S-0522-YC5203)
Target: CD3
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5205) (CAT#: V3S-0522-YC5205)
Target: CD3
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5206) (CAT#: V3S-0522-YC5206)
Target: CD3
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5207) (CAT#: V3S-0522-YC5207)
Target: CD3
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5209) (CAT#: V3S-0522-YC5209)
Target: CD3
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5210) (CAT#: V3S-0522-YC5210)
Target: CD3
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5211) (CAT#: V3S-0522-YC5211)
Target: CD3
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5212) (CAT#: V3S-0522-YC5212)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5213) (CAT#: V3S-0522-YC5213)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5214) (CAT#: V3S-0522-YC5214)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5215) (CAT#: V3S-0522-YC5215)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5216) (CAT#: V3S-0522-YC5216)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5217) (CAT#: V3S-0522-YC5217)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5218) (CAT#: V3S-0522-YC5218)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5219) (CAT#: V3S-0522-YC5219)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5220) (CAT#: V3S-0522-YC5220)
Target: CD3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5221) (CAT#: V3S-0522-YC5221)
Target: CD3
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5222) (CAT#: V3S-0522-YC5222)
Target: CD3
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5223) (CAT#: V3S-0522-YC5223)
Target: CD3
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5224) (CAT#: V3S-0522-YC5224)
Target: CD3
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,SPR,
Recombinant Anti-CD3 Antibody (V3S-0522-YC5225) (CAT#: V3S-0522-YC5225)
Target: CD3
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,SPR,
Recombinant Anti-CD3 Antibody (V3S-1022-YC2241) (CAT#: V3S-1022-YC2241)
Target: CD3
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,FC,
Recombinant Anti-CD3 Antibody (V3S-1022-YC2242) (CAT#: V3S-1022-YC2242)
Target: CD3
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,FC,
