CD36 Specific Neutra™ Antibody Products

CD36 (CD36 Molecule), also known as platelet glycoprotein 4 or SCARB3, is a ubiquitous integral membrane protein found on the surface of multiple cell types, such as microvascular endothelial cells, phagocytes, erythroid precursor cells, skeletal muscle cells, and mammary epithelial cells. CD36 is capable of binding a variety of ligands, including collagen, thrombospondin, long-chain fatty acids as well as native lipoproteins.

Its Gene ID: 948, UniProtKB ID: P16671, and OMIM ID: 173510.

Functions

CD36 has multiple biological functions. It is reported to be involved in the management of diverse metabolic pathways, such as fat taste perception, chylomicron production, and eicosanoid formation. In addition, CD36 is also considered to be a hub for parenchymal cell fatty acid uptake and regulates glucose and insulin metabolism. Another crucial function of CD36 is to directly mediate cell adhesion of erythrocytes. In addition, as a regulator of angiogenesis, CD36 is also closely linked to tumor growth and wound healing.

CD36 Pathways

Increasing evidence suggests that the function of CD36 is associated with the activation of src family kinases as well as the mitogen-activated protein (MAP) kinases. In addition, there are data suggesting that CD36-mediated platelet activation is linked to the MAP kinase pathway.

Fig.1 CD36 signal transduction in pancreatic β-cell dysfunction.¹

Related Diseases

CD36 is a critical regulator of fatty acid metabolism, heart disease, and intestinal fat processing. Increasing evidence suggests that CD36 may be closely linked to a variety of diseases, including atherosclerosis, glucose intolerance, diabetes, arterial hypertension, cardiomyopathy, and Alzheimer's disease. In addition, CD36 also serves as an important factor in the occurrence of various cancers, such as liver cancer and glioma. It is noteworthy that CD36 also participates in the regulation of inflammatory responses and atherothrombotic disease. It has been reported that CD36 may also be a promoter of obesity.

Therapies Targeting CD36

Function-blocking antibodies targeting CD36 have been reported to effectively reduce tumor metastasis in gastric and ovarian cancer mice. Furthermore, targeting CD36 has been shown to elicit antitumor immunity in immunocompetent mice, thus providing new horizons for CD36-targeted therapy in cancer.

CD36 Antibodies

Dozens of CD36 antibodies are available at Creative Biolabs. Our validated antibodies targeting CD36 are suitable for WB, FC, IHC, and ELISA applications. If you need monoclonal antibodies, polyclonal antibodies, or neutralizing antibodies targeting CD36, please contact us for a detailed quote on CD36 antibodies.

REFERENCE

1. Karunakaran, Udayakumar, et al. "CD36 signal transduction in metabolic diseases: novel insights and therapeutic targeting." Cells 10.7 (2021): 1833. Distributed under Open Access license CC BY 4.0, without modification.