CD40 ligand (CD40LG) is a cytokine, also known as CD40L. The membrane-bound CD40LG is a single-pass type II membrane protein mainly expressed on activated CD4+ T cells and induces apoptosis. Upon binding with the CD40 receptor, the membrane-bound CD40LG is cleaved into a soluble form. The soluble form protein is secreted intracellularly and plays a role in cell death induction. CD40LG interacts with CD40, a member of the TNF-receptor superfamily. The CD40-CD40LG signaling cascade transduces various cell type-specific immune responses.
Its UniProtKB ID: P29965, Gene ID: 959, and OMIM ID: 300386.
As shown in Figure 1, CD40LG interacts with its receptors such as αMβ2, α2bβ3, α5β1, and its "classical" receptor CD40. The trimeric D40LG complexes interact with CD40 in a homotrimer or heterotrimer fashion. CD40LG induces cell type-specific downstream signaling events including the recruitment of TRAFs and the engagement of NF-κB, MAPKs, and PI3K.
Fig.1 Interactions of CD40LG and its receptors.1
Due to its indispensable role in B cell activation and antibody production, CD40LG is a compelling signal pathway modulator in inflammation and autoimmune diseases. Treatment strategies based on CD40LG are currently being investigated for several diseases:
Tab. 1 CD40LG-associated target molecules in atherosclerosis research.1
Creative Biolabs always strives to offer high-quality antibody products to meet our customers needs. We provide professional consultation and various anti-CD40LG antibodies for related immune and functional assays.
Fig.2 Recombinant huCD40LG was detected with the anti-CD40LG antibody (V3S-0622-YC1332) in ELISA.
Fig.3 Dot blot analysis of anti-CD40LG antibody (V3S-0622-YC1332) with recombinant huCD40LG protein.
Anti-CD40LG Neutralizing Antibody (V3S-0622-YC1332) (CAT#: V3S-0622-YC1332)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: WB,DB,IF,IP,Neut,FuncS,ELISA,FC,ICC,
Recombinant Anti-CD40LG (aa 129-250) Antibody (V3S-0522-YC4796) (CAT#: V3S-0522-YC4796)
Target: CD40LG
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5322) (CAT#: V3S-0522-YC5322)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5325) (CAT#: V3S-0522-YC5325)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5326) (CAT#: V3S-0522-YC5326)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5327) (CAT#: V3S-0522-YC5327)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5328) (CAT#: V3S-0522-YC5328)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5329) (CAT#: V3S-0522-YC5329)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5330) (CAT#: V3S-0522-YC5330)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5331) (CAT#: V3S-0522-YC5331)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5332) (CAT#: V3S-0522-YC5332)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5333) (CAT#: V3S-0522-YC5333)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5334) (CAT#: V3S-0522-YC5334)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5335) (CAT#: V3S-0522-YC5335)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5336) (CAT#: V3S-0522-YC5336)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: FC,ELISA,
Recombinant Anti-CD40LG Antibody (V3S-0522-YC5337) (CAT#: V3S-0522-YC5337)
Target: CD40LG
Host Species: Human
Target Species: Human,
Application: ELISA,
Anti-CD40LG (aa 50-261) Neutralizing Antibody (V3S-0822-YC732) (CAT#: V3S-0822-YC732)
Target: CD40LG
Host Species: Mouse
Target Species: Human,
Application: FC,IHC,CyTOF,Neut,WB,
Anti-CD40LG Neutralizing Antibody (V3S-0822-YC733) (CAT#: V3S-0822-YC733)
Target: CD40LG
Host Species: Mouse
Target Species: Human, Hamster,
Application: Neut,ELISA,FC,FuncS,ICC,IF,
Anti-CD40LG Neutralizing Antibody (V3S-0822-YC737) (CAT#: V3S-0822-YC737)
Target: CD40LG
Host Species: Rat
Target Species: Mouse,
Application: FC,CyTOF,Neut,
Recombinant Rat Anti-CD40LG Antibody (V3S-1222-YC252) (CAT#: V3S-1222-YC252)
Target: CD40LG
Host Species: Rat
Target Species: Human,
Application: FC,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC684) (CAT#: V3S-1222-YC684)
Target: CD40LG
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC685) (CAT#: V3S-1222-YC685)
Target: CD40LG
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC686) (CAT#: V3S-1222-YC686)
Target: CD40LG
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1450) (CAT#: V3S-1222-YC1450)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1451) (CAT#: V3S-1222-YC1451)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1452) (CAT#: V3S-1222-YC1452)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1453) (CAT#: V3S-1222-YC1453)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1454) (CAT#: V3S-1222-YC1454)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1455) (CAT#: V3S-1222-YC1455)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
Recombinant Anti-CD40LG Antibody (V3S-1222-YC1456) (CAT#: V3S-1222-YC1456)
Target: CD40LG
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,
