EV-D68 VP1 Specific Neutra™ Antibody Products

Do you presently meet difficulties in efficacious therapeutics or diagnostics developments for Enterovirus D68 (EV-D68) infections? Our EV-D68 VP1 Specific Neutra™ Antibody Products are well-designed for you. To facilitate an expedited research and development process by offering high-caliber reagents for the specific targeting and neutralization of EV-D68 virions.

Introduction of EV-D68 VP1

The Enterovirus D68 (EV-D68) poses a major public health challenge within the non-poliovirus enterovirus family. EV-D68 primarily targets children because it consistently leads to severe respiratory conditions. The critical function of VP1 capsid protein in EV-D68 infection mechanisms establishes it as a prime target for the development of treatments and diagnostic tests to fight EV-D68 diseases.

EV-D68 VP1 Structure

The EV-D68 virus has an icosahedral protein shell surrounding its RNA genome. This capsid structure is constituted by four distinct structural proteins: VP1, VP2, VP3, and VP4. Among all structural proteins VP1 stands out as the largest surface protein that is most externally accessible on the viral particle.

Related Signaling Pathways

EV-D68 infection initiates complicated signaling pathway interactions within host cells. Viral attachment to host cell receptors initiates multiple processes such as viral entry followed by replication and release from the host cell. The PI3K/Akt pathway along with the MAPK pathway and NF-κB function as essential components throughout these cellular processes.

Fig. 1 EV-D68 strategically targets key molecules within the TLR and RLR pathways to evade innate immune responses.¹

Application for Anti-EV-D68 VP1 Antibody

Monitoring Viral Evolution

VP1 antibodies intended against EV-D68 serve essential functions for understanding how the virus progresses and changes. The VP1 protein functions as an important antigenic site where any sequence modifications may alter antibody binding. Researchers can track viral evolution and spot emerging EV-D68 variants through the analysis of antibody interactions across multiple virus strains. The data collected is essential for creating comprehensive vaccines and therapeutic antibodies that work against multiple EV-D68 virus variants.

Understanding Pathogenesis

Research into the pathogenic mechanisms of EV-D68 depends on VP1-specific antibodies. Research applications of these antibodies include studying interactions between the virus and host cells while identifying infected cell types and analyzing viral transmission methods within the body. Through immunohistochemistry using anti-VP1 antibodies, scientists can track the virus distribution in affected tissues to understand the pathogenesis of EV-D68-related respiratory and neurological conditions.

Creative Biolabs continues our unwavering commitment to supplying EV-D68 VP1 Specific Neutra™ Antibody Products of exceptional quality. Purposefully engineered to fortify your research and development endeavors.

REFERENCE

1. Sun, Jing, Xiao-Yi Hu, and Xiao-Fang Yu. "Current understanding of human enterovirus D68." Viruses 11.6 (2019): 490. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/v11060490