FAP Specific Neutra™ Antibody Products

Fibroblast Activation Protein Alpha (FAP), also known as Integral Membrane Serine Protease or DPPIV, is a crucial member of the serine protease family. FAP is a homodimer membrane gelatinase. Under normal physiological conditions, the expression of FAP is undetectable. Under some pathological conditions, such as cancer and arthritis, FAP is selectively expressed in some cells and tissues. For example, FAP has been found to be expressed in malignant cells of soft tissue and bone. Notably, elevated FAP is generally linked to poorer clinical outcomes in diverse cancer types.

Its Gene ID: 2191, UniProtKB ID: Q12884, and OMIM ID: 600403.

Function

Accumulating results indicate that FAP is an important regulator of tissue repair, development, extracellular matrix degradation, and fibroblast growth in epithelial cancers. FAP is also closely linked to many cellular processes, including wound healing, tissue remodeling, fibrosis, and inflammation. Furthermore, FAP expression regulates tumor growth by participating in a variety of physiological processes, including tumor cell invasion and proliferation, angiogenesis, and immune suppression.

Fig.1 Schematic representations of FAP structural compositions and its protein scaffold.^1,3

FAP and Diseases

• Non-oncologic disease

FAP is thought to be associated with the development of a variety of diseases, including atherosclerosis, arthritis, autoimmune diseases, and metabolic diseases. Much evidence suggests that FAP may contribute to increased disease severity.

• Cancer

FAP is overexpressed in many cancers, such as lung cancer, breast cancer, bladder cancer, colorectal cancer, ovarian cancer, and pancreatic cancer. Typically, FAP is abundantly expressed in the stroma. Currently, FAP has gradually emerged as a marker for cancer-associated fibroblasts.

FAP Signaling Pathways

FAP is closely associated with multiple downstream signaling pathways, including RAS/ERK, PI3K/AKT, SHH/GLI and FAK. For example, in osteosarcoma cells, FAP is involved in the regulation of angiogenesis through the ERK and AKT signaling pathways. Furthermore, in oral squamous cell carcinoma, FAP regulates cell proliferation through the ERK and PI3K/AKT signaling pathways.

Fig.2 The signaling pathway in FAP regulation.^2,3

Therapeutics Targeting FAP

Currently, scientists are trying to inhibit FAP activity with antibodies. The possible diagnostic and therapeutic potential of antibodies directed against FAP has been reported. It is noteworthy that clinical studies and pharmacokinetic analyzes of a humanized anti-FAP antibody have revealed the promising clinical value of FAP antibodies.

FAP Antibodies

As an expert in the field of antibody research and development, Creative Biolabs is confident in providing high-standard FAP antibody products to customers around the world. Our antibodies include FAP monoclonal antibodies, FAP polyclonal antibodies, and FAP neutralizing antibodies. Our FAP antibodies are suitable for a variety of scientific research, including ICC, IP, IHC-P and WB. Lot-to-lot consistency of FAP antibody products is guaranteed at Creative Biolabs. For more information about FAP antibodies, please do not hesitate to contact us.

REFERENCES

1. Imlimthan, Surachet, et al. "New frontiers in cancer imaging and therapy based on radiolabeled fibroblast activation protein inhibitors: a rational review and current progress." Pharmaceuticals 14.10 (2021): 1023.
2. Shi, Yixin, et al. "Oncogenesis, microenvironment modulation and clinical potentiality of FAP in glioblastoma: lessons learned from other solid tumors." Cells 10.5 (2021): 1142.
3. Distributed under Open Access license CC BY 4.0, without modification.