FcRn Specific Neutra™ Antibody Products

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Fc receptor (FcRn) is known as neonatal Fc receptor and FCGRT. FcRn regulates the transportation and recycling of immunoglobulin G (IgG) molecules in a pH-dependent way. FcRn is associated with many immune diseases such as immunodeficiency and immunoglobulin G deficiency.

Its Gene ID: 2217, UniProtKB ID: P55899, and OMIM ID: 601437.

Functions of FcRn in Immune Responses

In collaboration with FcγRs, FcRn functions in innate immune activities. The mechanisms of FcRn in reaction with IgG immune complexes (IgG-IC) are shown here.

Enhances the production of tissue factors and pro-inflammatory cytokines.
Facilitates the phagocytosis of IgG-opsonized bacteria.
Promotes in the antigen presentation and cross-presentation.

Fig.1 The roles of FcRn in native immune cells.¹

Treatment Strategy about FcRn in Autoimmune Diseases

One characterization of autoimmune diseases is the excess autoantibody production leading to cell dysfunction or tissue destruction. For its role in recycling the IgG autoantibodies, FcRn plays a central role in autoimmunity. FcRn-related treatment strategy for autoimmune diseases is shown in Fig.2.

Therapeutic monoclonal antibodies targeting FcRn inhibit the IgG-IC-mediated activation of immune cells and phagocytosis.
Acting as FcRn inhibitors, exogenous IgGs saturate FcRn and enhance the reduction of pathogenic IgG autoantibodies.

The roles of FcRn in native immune cells. Fig.2 FcRn targeting strategy in autoimmune diseases.²

Creative Biolabs offers many anti-FcRn antibodies applicable in immunoassays and functional assays. With their high purity and validated specificity, these antibodies could be used in the research of immunotherapies for cancer, inflammation, and autoimmune diseases.

Fig.3 Human FcRn Protein was detected by anti-FcRn antibody (V3S-0622-YC1604) in Western blot.

Fig.4 Human FcRn protein was serially diluted and probed with anti-FcRn antibody (V3S-0622-YC1604) in Dot blot.

REFERENCES

Pyzik, Michal, et al. "The therapeutic age of the neonatal Fc receptor." Nature Reviews Immunology (2023): 1-18.
Qi, Timothy, and Yanguang Cao. "In translation: FcRn across the therapeutic spectrum." International Journal of Molecular Sciences 22.6 (2021): 3048.

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Anti-FcRn Neutralizing Antibody (V3S-0622-YC1604) (CAT#: V3S-0622-YC1604)

Target: FcRn

Host Species: Human

Target Species: Human,

Application: ELISA,WB,DB,FuncS,