IGF1R, a critical transmembrane tyrosine kinase widely present in mammalian cells, is recognized for its activation signal as one of the most effective axes governing cell survival and apoptosis, essential for the regulation of cellular growth and proliferation. Functioning as a pivotal surface receptor, IGF1R orchestrates intracellular signaling pathways upon binding with its primary ligands, IGF1 or insulin, thereby shaping the fate of cells.
Its Gene ID: 3480, UniProtKB ID: P08069, and OMIM ID: 147370.
Regarding its structure and functionality, the IGF1R receptor comprises multiple structural domains including L1, CR, L2, FnIII, etc. Upon binding with its primary ligands IGF1 or insulin, IGF1R phosphorylates insulin receptor substrates 1 and 2 (IRS1 and IRS2) and recruits downstream effector molecules.
Fig.1 Structure of IGF1R and IGF1.1
IGF1R engages in signal transduction through various intracellular substrates, thereby activating the phosphoinositide 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK) pathways. PI3K/AKT pathway orchestrates a multitude of critical cellular processes encompassing proliferation and apoptosis, whereas the Ras/MAPK pathway fosters cellular differentiation and proliferation.
Fig.2 Signaling of IGF1R.2
IGF1R plays pivotal roles across a spectrum of diseases. During viral infections, certain viruses exploit the IGF1R signaling pathway to gain entry into host cells. Elevated levels of IGF1R observed in COVID-19-related ARDS patients underscore its significance in disease progression. Studies also believe that specific viruses will use host transcription factors in the Ras/Raf/MEK/ERK pathway or encode peptides similar to insulin or IGF1 to affect the host's pathological behavior and evade immune system attack.
Dysregulation of IGF1R correlates closely with conditions such as growth retardation and cancer, with its overexpression associated with tumorigenesis and therapeutic resistance. There is also a view that the expression of IGF1R is associated with poor prognosis in patients with tumor types including pancreatic cancer, colorectal cancer, ovarian cancer, etc. Neutralizing antibodies against IGF1R are considered viable potential tumor intervention strategies.
Fig.3 IGF1R in cancer immunology.3
IGF1R antibodies serve as vital research tools, offering novel avenues for delving deeper into the mechanisms governing cellular growth regulation. Committed to furnishing premium IGF1R-related antibody products and a cutting-edge neutralizing antibody and recombinant antibody technology platform, Creative Biolabs endeavors to facilitate significant strides in scientific exploration, contributing towards advancements in human health and paving the way for innovative strategies in disease prevention and treatment.
As a pioneer in the neutralizing antibody sector, Creative Biolabs is committed to delivering top-tier services and products to clients worldwide. Please feel free to reach out to us for more information.
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC4575) (CAT#: V3S-0622-YC4575)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: FC,IP,ELISA,Neut,FuncS,IF,ICC,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0622-YC259) (CAT#: V3S-0622-YC259)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Block,FC,FuncS,
Anti-IGF1R (FnR3 domain) Neutralizing Antibody (V3S-0622-YC260) (CAT#: V3S-0622-YC260)
Target: IGF1R
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,FC,Inhib,FuncS,
Anti-IGF1R (FnR3 domain) Neutralizing Antibody (V3S-0622-YC261) (CAT#: V3S-0622-YC261)
Target: IGF1R
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,Inhib,FuncS,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC262) (CAT#: V3S-0622-YC262)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Inhib,FuncS,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC263) (CAT#: V3S-0622-YC263)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Inhib,FuncS,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1775) (CAT#: V3S-0622-YC1775)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1776) (CAT#: V3S-0622-YC1776)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,Neut,FC,IHC,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0622-YC1777) (CAT#: V3S-0622-YC1777)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,WB,Inhib,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0622-YC1778) (CAT#: V3S-0622-YC1778)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,WB,Inhib,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1780) (CAT#: V3S-0622-YC1780)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,Inhib,IP,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1781) (CAT#: V3S-0622-YC1781)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: IP,IHC,ELISA,FC,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1782) (CAT#: V3S-0622-YC1782)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: IP,IHC,ELISA,FC,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1783) (CAT#: V3S-0622-YC1783)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1784) (CAT#: V3S-0622-YC1784)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Neut,FC,IHC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1785) (CAT#: V3S-0622-YC1785)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Neut,FC,IHC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1786) (CAT#: V3S-0622-YC1786)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Inhib,IP,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1787) (CAT#: V3S-0622-YC1787)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,IHC,IF,WB,
Recombinant Anti-IGF1R (ECD domain) Antibody (V3S-0622-YC1788) (CAT#: V3S-0622-YC1788)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,IF,IP,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1789) (CAT#: V3S-0622-YC1789)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,WB,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1790) (CAT#: V3S-0622-YC1790)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,WB,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1791) (CAT#: V3S-0622-YC1791)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1792) (CAT#: V3S-0622-YC1792)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1793) (CAT#: V3S-0622-YC1793)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IGF1R (ECD domain) Antibody (V3S-0622-YC1794) (CAT#: V3S-0622-YC1794)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1795) (CAT#: V3S-0622-YC1795)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: IF,IP,Neut,FuncS,ELISA,FC,WB,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1796) (CAT#: V3S-0622-YC1796)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1797) (CAT#: V3S-0622-YC1797)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Neut,FC,IHC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC1798) (CAT#: V3S-0622-YC1798)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Inhib,IP,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1799) (CAT#: V3S-0622-YC1799)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IGF1R Antibody (V3S-0622-YC1800) (CAT#: V3S-0622-YC1800)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC3466) (CAT#: V3S-0622-YC3466)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,Block,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC4572) (CAT#: V3S-0622-YC4572)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC4573) (CAT#: V3S-0622-YC4573)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: FC,IP,ELISA,Neut,FuncS,IF,ICC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC4574) (CAT#: V3S-0622-YC4574)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: WB,IF,IP,Neut,FuncS,ELISA,FC,
Anti-IGF1R Neutralizing Antibody (V3S-0622-YC4576) (CAT#: V3S-0622-YC4576)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: FuncS,IF,Neut,ELISA,FC,IP,ICC,
Anti-IGF1R Neutralizing Antibody (V3S-0522-YC583) (CAT#: V3S-0522-YC583)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Neut,
Anti-IGF1R Neutralizing Antibody (V3S-0522-YC584) (CAT#: V3S-0522-YC584)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Neut,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0522-YC585) (CAT#: V3S-0522-YC585)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0522-YC586) (CAT#: V3S-0522-YC586)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0522-YC587) (CAT#: V3S-0522-YC587)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-IGF1R (ECD domain) Neutralizing Antibody (V3S-0522-YC588) (CAT#: V3S-0522-YC588)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Inhib,
Anti-IGF1R Neutralizing Antibody (V3S-0522-YC589) (CAT#: V3S-0522-YC589)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,Inhib,
Anti-IGF1R Neutralizing Antibody (V3S-0522-YC590) (CAT#: V3S-0522-YC590)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,Inhib,
Anti-IGF1R Neutralizing Antibody (V3S-0522-YC591) (CAT#: V3S-0522-YC591)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,Inhib,
Recombinant Anti-IGF1R Antibody (V3S-0522-YC592) (CAT#: V3S-0522-YC592)
Target: IGF1R
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,FuncS,
Recombinant Anti-IGF1R Antibody (V3S-0522-YC593) (CAT#: V3S-0522-YC593)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,FuncS,
Recombinant Anti-IGF1R (ECD domain) Antibody (V3S-0522-YC594) (CAT#: V3S-0522-YC594)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IGF1R (ECD domain) Antibody (V3S-0522-YC595) (CAT#: V3S-0522-YC595)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IGF1R (ECD domain) Antibody (V3S-0522-YC2332) (CAT#: V3S-0522-YC2332)
Target: IGF1R
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
