IL13 Specific Neutra™ Antibody Products

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Belonging to the Type I cytokines family, IL-13 assumes a critical role in immune modulation and neuroprotection, acknowledged widely as a pivotal mediator immune response in the pathogenesis of allergic inflammation. Anti-IL13 monoclonal antibodies can be used as reagents for scientific research, especially neutralizing antibodies that block IL13 activity.

Structural Characteristics and Expression of IL-13

Like IL-4, IL-13 features a tertiary structure comprised of four α-helical hydrophobic bundles. Its genetic composition consists of a singular open reading frame encompassing 132 amino acids, inclusive of a 20-amino acid signal sequence that undergoes cleavage to form the mature secretory protein.

IL-13's expression predominantly occurs in activated YH2 cells, while its receptors manifest widespread presence on various cell surfaces such as human B cells, eosinophils, basophils, mast cells, endothelial cells, and fibroblasts.

Fig.1 IL-13 and IL-4 share receptors and signaling pathways.¹

Principal Functions of IL-13

IL-13 and IL-4

Serving as an immunoregulatory cytokine discharged by activated TH2 cells, IL-13 shares receptors with IL-4, notably the IL-4Rα, Type II IL-4R/IL-13R, and IL-13Rα2. It also shares signaling pathways, including the JAK/STAT pathway and IRS-1/IRS-2 pathway, with IL-4. IL-13 exerts potent immunomodulatory effects and partakes in processes such as regulation of mucosal immune responses, expression of cell adhesion molecules, and proliferation of B cells.

Additional Roles of IL-13

Studies indicate that while IL-13 bears functional resemblances to IL-4, it displays distinct functional attributes in certain contexts. IL-13 can foster survival, activation, and recruitment of eosinophils, stimulate immunoglobulin E synthesis in mast cells, induce vascular cell adhesion molecule 1 in endothelial cells, and enhance chemokine expression in epithelial cells. Furthermore, IL-13 has been implicated in neuroprotection.

Fig.2 Functions of IL-13. (Hershey, 2003) Fig.2 Functions of IL-13.¹

IL-13 and Associated Disorders

The functional characteristics of IL-13 render it a promising therapeutic target for intervention in allergic diseases. It assumes a pivotal role in the progression of allergic inflammation, airway hyperreactivity, and mucus production, particularly significant in asthma treatment. Additionally, IL-13 has been implicated in neuroprotection, with upregulation of IL-13 observed to safeguard neurons against excitotoxic death, offering novel avenues and intervention strategies for addressing the pathophysiology of brain trauma.

Fig.3 IL-13 in neuroprotection.²

What Sets Us Apart

As a leading biotechnology enterprise, Creative Biolabs is dedicated to furnishing top-tier neutralizing antibody and recombinant antibody-related services and technical platforms to bolster research endeavors focusing on IL-13 and other targets. Our services span across various applications, encompassing research, clinical diagnosis, and drug development. Moreover, we possess the capability to deliver antibodies in diverse specifications and purities to accommodate varied research requisites. Please do not hesitate to contact us for any demands.

REFERENCES

Hershey. "IL-13 receptors and signaling pathways: An evolving web." Molecular Mechanisms in Allergy and Clinical Immunology (2003).
Li, Heuvel, et al. "Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection." Nature Communications 14 (2023):200.

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