IL13RA2 Specific Neutra™ Antibody Products

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Interleukin 13 receptor subunit alpha 2 (IL13RA2), also known as IL-13R or IL-13Rα2, is a single-pass type I membrane protein located on the cell membrane. It binds with a high affinity to IL13, a regulatory cytokine involved in B-cell maturation and differentiation. This protein is overexpressed in normal tissues, like archives, testis, and brain. IL13RA2 is associated with many diseases such as glioblastoma, interstitial lung disease, and brain cancer.

Its Gene ID: 3598, UniProtKB ID: Q14627, and OMIM ID: 300130.

Functions of Blockade of the IL13RA2 Pathway

The IL-13 and IL13RA2 interaction (Fig.1A) activates SRC and subsequently induces the PI3K / AKT, ERK, and FAK signaling cascades, which finally promotes the survival, proliferation, migration/invasion of tumor cells.

The CHI3L1 and IL13RA2 interaction (Fig.1B) activates the signaling pathways to regulate apoptosis, pyroptosis, inflammation activation, and tumor metastasis.

Fig.1 Molecular mechanisms of IL13RA2 signaling pathways in tumor growth and metastasis.¹

Treatment Strategies by targeting IL13RA2

Anti-tumor strategies targeting the IL13RA2 pathway are under hot investigation for IL13RA2-positive tumors. These IL13RA-associated therapeutic strategies include immunotoxins, tumor vaccines, monoclonal antibodies, antibody-drug conjugates (ADC), CAR T cells, and peptide-drug conjugates. These strategies have both advantages and disadvantages in generating antitumor invasion and metastasis effects.

Molecular mechanisms of IL13RA2 signaling pathways in tumor growth and metastasis. Fig.2 Strategies by targeting IL13RA2 in anti-tumor therapies.²

Creative Biolabs offers anti-IL13RA2 antibodies with applications for immunoassays and functional assays. These antibodies with good quality could be used in deciphering IL13RA2 molecular mechanisms and cancer research.

Fig.3 Human IL13RA2 protein was detected using anti-IL13RA2 antibody (V3S-0622-YC1843) by ELISA.

Fig.4 Human IL13RA2 protein was probed with anti-IL13RA2 antibody (V3S-0622-YC1843) in Western blot.

Fig.5 Human IL13RA2 protein was detected with anti-IL13RA2 antibody (V3S-0622-YC1843) in Dot blot.

REFERENCES

Jaén, Marta, et al. "Interleukin 13 receptor alpha 2 (IL13Rα2): Expression, signaling pathways and therapeutic applications in cancer." Biochimica et Biophysica Acta (BBA)-Reviews on Cancer (2022): 188802.
Knudson, Karin M., et al. "Recent advances in IL-13rα2-directed cancer immunotherapy." Frontiers in Immunology 13 (2022): 878365.

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