Interleukin 17 Receptor A (IL17RA), also known as IL17R, is the receptor for the proinflammatory cytokine IL17A. IL17RA has two isoforms. Isoform 1 is a membrane-bound protein and isoform 2 is a secreted protein. IL17RA is associated with many diseases such as immunodeficiency, psoriasis, and cancer.
Its Gene ID: 23765, UniProtKB ID: Q96F46, and OMIM ID: 605461.
IL-17 cytokine family consists of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17RA, IL-17RB, IL-17RC, IL-17RD and IL-17RE are five distinct receptors of the IL-17 receptor family. IL-17RA is the common subunit for all the heterodimeric IL-17 receptors. The IL-17RA and IL-17RC complex is the main receptor for the transduction of IL17 downstream signaling pathways.
Fig.1 IL-17 cytokine and receptor families.1
As shown in Fig.2, the EGFR-IL17A-IL17R axis plays a crucial role in cancer genesis and progression. In Lrig1⁺ tumor stem cells, the interaction of IL-17A and IL-17R helps EGFR to bind tightly with TRAF4 and then promotes Act1 to recruit c-Src for the activation of downstream pathways such as MEK5 and ERK5. Thus, Lrig1⁺ cancer stem cells proliferate and differentiate rapidly during carcinogenesis.
Fig.2 Activation of the EGFR-IL17A-IL17R axis.1
Creative Biolabs offers anti-IL17RA antibodies with applications for functional and immunoassays. These antibodies with good quality could be used in autoimmune disorders and cancer studies.
Fig.3 ELISA analysis of anti-IL17RA antibody (V3S-0622-YC1899) with human IL17RA protein (His tag).
Fig.4 Western blot was performed with anti-IL17RA antibody (V3S-0622-YC1899) and human IL17RA protein in different concentrations.
Fig.5 Human IL17RA protein was detected with anti-IL17RA antibody (V3S-0622-YC1899) in Dot blot.
Anti-IL17RA Neutralizing Antibody (V3S-0622-YC1899) (CAT#: V3S-0622-YC1899)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: WB,DB,Neut,ELISA,IF,IP,FuncS,FC,ICC,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3504) (CAT#: V3S-0622-YC3504)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3505) (CAT#: V3S-0622-YC3505)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3506) (CAT#: V3S-0622-YC3506)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3507) (CAT#: V3S-0622-YC3507)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3508) (CAT#: V3S-0622-YC3508)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,WB,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3509) (CAT#: V3S-0622-YC3509)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,WB,
Recombinant Anti-IL17RA Antibody (V3S-0622-YC3510) (CAT#: V3S-0622-YC3510)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: ELISA,FC,WB,
Anti-IL17RA Neutralizing Antibody (V3S-0622-YC4593) (CAT#: V3S-0622-YC4593)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: WB,ELISA,FC,IP,FuncS,IF,Neut,
Anti-IL17RA Neutralizing Antibody (V3S-0822-YC1595) (CAT#: V3S-0822-YC1595)
Target: IL17RA
Host Species: Mouse
Target Species: Human,
Application: FuncS,Neut,
Anti-IL17RA Neutralizing Antibody (V3S-0822-YC1596) (CAT#: V3S-0822-YC1596)
Target: IL17RA
Host Species: Mouse
Target Species: Human,
Application: Neut,WB,
Anti-IL17RA Neutralizing Antibody (V3S-0822-YC1597) (CAT#: V3S-0822-YC1597)
Target: IL17RA
Host Species: Mouse
Target Species: Human,
Application: WB,FC,CyTOF,Neut,
Anti-IL17RA (ECD domain) Neutralizing Antibody (V3S-0822-YC1598) (CAT#: V3S-0822-YC1598)
Target: IL17RA
Host Species: Mouse
Target Species: Human,
Application: Neut,WB,
Anti-IL17RA Neutralizing Antibody (V3S-0822-YC1599) (CAT#: V3S-0822-YC1599)
Target: IL17RA
Host Species: Rabbit
Target Species: Human,
Application: Neut,
Anti-Il17ra Neutralizing Antibody (V3S-0822-YC1600) (CAT#: V3S-0822-YC1600)
Target: Il17ra
Host Species: Rat
Target Species: Mouse,
Application: FC,CyTOF,Neut,
Recombinant Anti-IL17RA Antibody (V3S-1022-YC700) (CAT#: V3S-1022-YC700)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: Activ,
Recombinant Anti-IL17RA Antibody (V3S-1022-YC701) (CAT#: V3S-1022-YC701)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL17RA (aa 220-284) Antibody (V3S-1022-YC1317) (CAT#: V3S-1022-YC1317)
Target: IL17RA
Host Species: Human
Target Species: Human,
Application: FC,
