IL6R Specific Neutra™ Antibody Products

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The Interleukin-6 Receptor (IL6R), as the primary receptor of Interleukin-6 (IL6), plays a crucial role in a variety of physiological and pathological processes. With the rapid development of the biomedical field, research and application of IL6R have become a focal point in this area. A deeper understanding of IL6R's signaling pathways and physiological functions, as well as its role in diseases, is of great significance for developing new treatment methods for IL6R-related autoimmune and chronic inflammatory diseases. Against this backdrop, Creative Biolabs is dedicated to providing a comprehensive introduction to IL6R and supporting clients in developing targeted therapies based on antibody drugs.

Physiological Functions of IL6R

The IL6 Receptor (IL6R) plays a key role in cell signal transduction, displaying the richness and importance of its biological functions through the following two main pathways:

(A) Classic IL6R/gp130 Signaling Pathway: This pathway involves the binding of IL6 to the membrane-bound IL6R (mIL6R) on the cell surface, further cooperating with gp130, triggering the activation of key signaling pathways such as JAK-STAT3. This complex and refined interaction process plays a vital role at multiple physiological levels, especially in regulating the growth and differentiation of immune cells, promoting liver regeneration, and maintaining cardiovascular health.

(B) Innovative Trans-Signaling Pathway: In this pathway, IL6 binds with the soluble IL6R (sIL6R), forming an active complex, and then interacts with gp130. The significance of this mechanism lies in its ability to activate cells that do not originally express IL6R, thereby significantly expanding the functional boundaries of IL6R and revealing its innovation and diversity in cell signal transduction.

Fig.1 Classic signaling and trans-signaling of IL-6.¹

Targeted IL6R Therapeutic Strategies

Abnormal activation of IL6R triggers a series of serious pathological responses, particularly in the immune system's excessive reaction to its own tissues. This response not only causes persistent inflammation but also leads to extensive tissue damage and various complications, including but not limited to:

Rheumatoid Arthritis
Systemic Lupus Erythematosus
Castleman's Disease
Erdheim-Chester Disease
Giant Cell Arteritis
Neuromyelitis Optica
Inflammatory Bowel Disease
Multiple Myeloma

Therefore, targeting the regulation of IL6R activity has become key in controlling these complex diseases. Currently, therapeutic strategies targeting IL6R have made significant progress in the development of anti-IL6R antibodies. The uniqueness of these antibodies lies in their ability to specifically bind and neutralize IL6R, effectively inhibiting its abnormal activation. In this way, they significantly alleviate inflammatory responses and reduce tissue damage, paving a new path for treating the aforementioned diseases.

Prospects of Anti-IL6R Antibody Applications

With a deeper insight into the role of the IL6/IL6R axis in pathology, the prospects for the application of anti-IL6R antibodies are rapidly expanding. These antibodies not only show great potential in the treatment of autoimmune diseases but their application may also extend to a wider range of disease types, including but not limited to:

Certain Types of Cancer: Using anti-IL6R antibodies to inhibit inflammatory responses in the tumor microenvironment may provide new strategies for cancer treatment.
Cardiovascular Diseases: These antibodies, by regulating inflammatory responses, are expected to play a significant role in the prevention and treatment of cardiovascular diseases.
Metabolic Diseases: In the treatment of diabetes, obesity, and other metabolic disorders, anti-IL6R antibodies may improve patient conditions by affecting inflammatory pathways.

In this new therapeutic field, Creative Biolabs' range of anti-IL6R neutralizing antibody products comes at an opportune time. Our products, with their high specificity and efficacy, provide innovative development options for researchers worldwide. In addition, we also offer customized antibody development services to meet your specific needs. Please feel free to contact us to explore the limitless possibilities of anti-IL6R antibodies in future treatments.

REFERENCE

Rose-John, S. Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer. FEBS Letters. 2022, 596(5):557-566.

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