LAMP1 Specific Neutra™ Antibody Products

Lysosomal-associated membrane protein 1 (LAMP1) is a type of glycoprotein that is primarily located in the lysosomal membrane. This protein plays an essential role in maintaining the integrity and functionality of lysosomes, including processes such as lysosomal biogenesis, trafficking, and fusion with other vesicles.

Its Gene ID: 3926, UniProtKB ID: P11279, and OMIM ID: 153330.

LAMP1 Biological Roles

• Biogenesis refers to the production of lysosomes by cells, a critical element of cellular function and homeostasis. LAMP1 helps to lead this process, ensuring the production of robust and functionally sound lysosomes.
• Trafficking, or the movement of lysosomes within the cell, is another crucial area where LAMP1 demonstrates its importance. Efficient trafficking of these organelles is fundamental to the cell's overall functionality; improper or disrupted lysosomal movement can lead to various cellular dysfunctions.
• LAMP1 is instrumental in the fusion of lysosomes with other vesicles within the cell. This fusion process is vital in numerous cellular tasks, including the degradation of waste materials, repair of the plasma membrane, and adaptive immune responses.
• LAMP1 acts as a receptor for certain pathogens, such as bacteria and viruses, mediating their entry into the cell and their subsequent degradation within the lysosome. This function implies an important role for LAMP1 in the host's defense system against pathogen invasion.
• Recent studies have also shown that LAMP1 is implicated in several diseases, including neurodegenerative disorders, cancers, and lysosomal storage diseases. Therefore, understanding the functions and regulatory mechanisms of LAMP1 could potentially lead to the development of therapeutic strategies for these disorders.

LAMP1 Pathway

• Lysosome pathway: As part of the lysosome, LAMP1 is integral to the functioning of this organelle. The lysosome pathway involves the breakdown and digestion of cellular components.
• Autophagy pathway: LAMP1 also plays a role in the autophagy process, which is the cellular mechanism of self-degradation and recycling of cellular components to maintain tissue homeostasis.
• Endocytosis pathway: LAMP1 is part of the endocytic pathway, which controls the intake of molecules into a cell and the subsequent delivery to the lysosomes.
• Immune response pathway: Besides, LAMP1 participates in the immune response by regulating the processing and presentation of antigens to T cells, a type of immune cell.
• Pathogen degradation pathway: LAMP1 is involved in the degradation of foreign invaders such as bacteria and viruses in the lysosomes, representing another facet of the immune response.
• Cell death (apoptosis) pathway: Finally, LAMP1 is associated with the cell death or apoptosis pathway and might have a role in the process of programmed cell death.

Fig.1 LAMP1 is involved in the autophagy-lysosome pathway.^{1, 3}

LAMP1 Antibody Therapeutics

Dysregulation of LAMP1 expression or function has been implicated in several diseases, including lysosomal storage disorders, neurodegenerative diseases, and cancer. In lysosomal storage disorders, mutations in genes encoding lysosomal proteins like LAMP1 lead to lysosomal dysfunction and accumulation of undegraded substances within cells. In cancer, altered expression of LAMP1 can influence tumor cell invasion, metastasis, and response to therapy.

LAMP1 antibodies have emerged as potential therapeutic agents in various diseases. In cancer therapy, LAMP1 antibodies can be utilized for targeted drug delivery to lysosomes within cancer cells, facilitating selective cytotoxicity. Additionally, LAMP1 antibodies can modulate immune responses by targeting lysosomal antigens, potentially enhancing antitumor immunity. In lysosomal storage disorders, LAMP1 antibodies may aid in restoring lysosomal function and reducing substrate accumulation, offering a potential therapeutic avenue for these debilitating conditions.

Fig.2 LAMP1 inhibition has the potential to reduce the efficiency of LASV entry and infection.^{2, 3}

LAMP1 exerts an essential role in lysosomal activity and function. Creative Biolabs provides LAMP1 antibody products for the study of LAMP1 in cancer and neuroscience.

REFERENCES

1. Xicoy, Helena, et al. "Autophagic-and lysosomal-related biomarkers for Parkinson’s disease: lights and shadows." Cells 8.11 (2019): 1317.
2. Hulseberg, Christine E., et al. "Lamp1 increases the efficiency of Lassa virus infection by promoting fusion in less acidic endosomal compartments." MBio 9.1 (2018): 10-1128.
3. Distributed under Open Access license CC BY 4.0. The image was modified by revising the title.