NOTCH3 Specific Neutra™ Antibody Products

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Notch Receptor 3 (Notch3), also known as Neurogenic Locus Notch Homolog Protein 3 or CADASIL, is an essential member of the Notch family. The Notch3 protein serves as a trigger across the cell membrane. One end of the Notch3 remains inside the cell and the other end protrudes from the surface of the cell. Some ligands bind to the outside of Notch3, which causes the ends of the Notch3 protein to dissociate within the cell. The separated fraction enters the nucleus to regulate gene expression.

Its Gene ID: 4854, UniProtKB ID: Q9UM47, and OMIM ID: 600276.

Fig.1 Domain structure map of the human Notch protein. Fig.1 Domain structure of human Notch proteins.^1,3

Function

Notch3 serves as a signaling receptor involved in the regulation of diverse developmental and cellular life events. Notch3 signaling is closely linked to stem cell survival and proliferation during embryonic development. In adults, Notch3 not only plays a crucial role in stem cell regulation but is also involved in regulating the survival and function of vascular smooth muscle cells. Notch3 also participates in the regulatory process of esophageal homeostasis. Furthermore, Notch3 has been reported to be a critical regulator of proinflammatory macrophage development.

Notch3 Signaling Pathways

The Notch3 signaling pathway is evolutionarily highly conserved. The Notch3 signaling pathway plays a crucial role in the development and cell specification of many organs. It has been reported that the Notch3 signaling pathway is one of the most commonly activated signaling pathways in cancer. Notch3 has been reported to play an essential function in activating NF-κB.

Fig.2 Notch network diagram. Fig.2 Notch crosstalk.^2,3

Notch3 and Disease

Notch3 is indispensable for tissue maintenance and renewal in the organism. Therefore, misregulation of Notch3 is closely related to the occurrence of many diseases. First of all, overexpression and incorrect activation of Notch3 can lead to the occurrence of various cancers, such as triple-negative breast cancer and ovarian cancer. Notch3 mutations have also been reported in Alzheimer's disease. Further evidence reveals that dysregulation of Notch3 contributes to the development of hypertensive disease. Furthermore, there are many other Notch3-associated diseases, such as subcortical infarction, leukoencephalopathy, and meningocele syndrome.

Notch3 Antibodies

In recent years, Notch3 has gradually emerged as a target for anti-cancer drugs. It has been reported that a Notch3 antibody related to cytotoxic drugs showed efficacy against solid tumors. At Creative Biolabs, multiple Notch3 antibodies are available, including but not limited to Notch3 neutralizing antibodies. You can choose the product that best suits your research purposes from our diverse Notch3 antibody portfolio. Contact our professional team to develop a customized plan for you.

REFERENCES

Hosseini-Alghaderi, Samira, and Martin Baron. "Notch3 in development, health and disease." Biomolecules 10.3 (2020): 485.
Giovannini, Catia, Luigi Bolondi, and Laura Gramantieri. "Targeting Notch3 in hepatocellular carcinoma: molecular mechanisms and therapeutic perspectives." International journal of molecular sciences 18.1 (2016): 56.
Distributed under Open Access license CC BY 4.0, without modification.

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