TNF Receptor Superfamily Member 4 (TNFRSF4), also known as OX40, is a single-pass type I membrane protein. It is a member of the TNFR superfamily of receptors that are overexpressed in normal tissues such as the spleen and whole blood. As a receptor of TNFSF4/OX40L/GP34, TNFRSF4 is a costimulatory molecule involved in cell immunity.
Its Gene ID is 7293, OMIM ID is 600315, and UniProtKB ID is P43489.
The agonistic TNFRSF4 costimulatory signaling on T cells could enhance the antitumor activity of the innate immune system. As shown in Figure 1, the signals TNFRSF4 transduced on immune cells are listed below:
Fig.1 Co-stimulation by TNFRSF4 TCRs and effects on antitumor T-cell immunity.1
The agonistic TNFRSF4 monoclonal antibodies (mAbs) are extensively studied in cancer immunotherapy. There are several anti-TNFRSF4 mAbs under investigation in preclinical or clinical trials (see Table 1). Some of the costimulatory anti-TNFRSF4 mAbs showed good antitumor effects such as tumor regression in many tumor types. TNFRSF4-based bispecific antibodies may overcome systemic toxicity by targeting the TNFRSF4 costimulatory protein to specific tumor sites.
Tab.1 Candidate immunotherapies targeting TNFRSF4 (OX40).1
Creative Biolabs offers all kinds of anti-TNFRSF4 antibodies involved in six research areas. These monoclonal antibodies were recombinantly expressed and their quality was strictly controlled.
Fig.2 SDS-PAGE analysis of anti-TNFRSF4 antibody (V3S-0522-YC1471).
Fig.3 TNFRSF4 protein was detected by ELISA using anti-TNFRSF4 antibody (V3S-0522-YC1471).
References
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1471) (CAT#: V3S-0522-YC1471)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: WB,ELISA,IHC,FC,IP,IF,FuncS,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC535) (CAT#: V3S-0622-YC535)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: Agonist,ELISA,FC,Stim,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2688) (CAT#: V3S-0622-YC2688)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2689) (CAT#: V3S-0622-YC2689)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2690) (CAT#: V3S-0622-YC2690)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2691) (CAT#: V3S-0622-YC2691)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2692) (CAT#: V3S-0622-YC2692)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2693) (CAT#: V3S-0622-YC2693)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2694) (CAT#: V3S-0622-YC2694)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2695) (CAT#: V3S-0622-YC2695)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2696) (CAT#: V3S-0622-YC2696)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC2697) (CAT#: V3S-0622-YC2697)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC3999) (CAT#: V3S-0622-YC3999)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC4000) (CAT#: V3S-0622-YC4000)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC4001) (CAT#: V3S-0622-YC4001)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC4002) (CAT#: V3S-0622-YC4002)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC4003) (CAT#: V3S-0622-YC4003)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: ELISA,WB,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC4004) (CAT#: V3S-0622-YC4004)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,
Recombinant Anti-TNFRSF4 Antibody (V3S-0622-YC4006) (CAT#: V3S-0622-YC4006)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,
Anti-TNFRSF4 Neutralizing Antibody (V3S-0622-YC5672) (CAT#: V3S-0622-YC5672)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1390) (CAT#: V3S-0522-YC1390)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1478) (CAT#: V3S-0522-YC1478)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,IHC,FC,IP,IF,FuncS,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1948) (CAT#: V3S-0522-YC1948)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: Agonist,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1949) (CAT#: V3S-0522-YC1949)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: Agonist,
Anti-TNFRSF4 Neutralizing Antibody (V3S-0522-YC1950) (CAT#: V3S-0522-YC1950)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,Inhib,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1951) (CAT#: V3S-0522-YC1951)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1952) (CAT#: V3S-0522-YC1952)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FuncS,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1953) (CAT#: V3S-0522-YC1953)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Anti-TNFRSF4 Neutralizing Antibody (V3S-0522-YC1954) (CAT#: V3S-0522-YC1954)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: FC,Block,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC1955) (CAT#: V3S-0522-YC1955)
Target: TNFRSF4
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,FuncS,
Anti-TNFRSF4 Neutralizing Antibody (V3S-0522-YC1956) (CAT#: V3S-0522-YC1956)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human, Cynomolgus, Monkey,
Application: ELISA,FC,Block,
Anti-TNFRSF4 (LBD region) Neutralizing Antibody (V3S-0522-YC1957) (CAT#: V3S-0522-YC1957)
Target: TNFRSF4
Host Species: Human
Target Species: Human, Cynomolgus, Monkey,
Application: ELISA,FC,Block,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6155) (CAT#: V3S-0522-YC6155)
Target: TNFRSF4
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,WB,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6158) (CAT#: V3S-0522-YC6158)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6161) (CAT#: V3S-0522-YC6161)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6164) (CAT#: V3S-0522-YC6164)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6167) (CAT#: V3S-0522-YC6167)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6170) (CAT#: V3S-0522-YC6170)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6172) (CAT#: V3S-0522-YC6172)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6176) (CAT#: V3S-0522-YC6176)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,WB,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6179) (CAT#: V3S-0522-YC6179)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6183) (CAT#: V3S-0522-YC6183)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6187) (CAT#: V3S-0522-YC6187)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6191) (CAT#: V3S-0522-YC6191)
Target: TNFRSF4
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6196) (CAT#: V3S-0522-YC6196)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6200) (CAT#: V3S-0522-YC6200)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6205) (CAT#: V3S-0522-YC6205)
Target: TNFRSF4
Host Species: Mouse
Target Species: Mouse,
Application: ELISA,RIA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6208) (CAT#: V3S-0522-YC6208)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF4 Antibody (V3S-0522-YC6211) (CAT#: V3S-0522-YC6211)
Target: TNFRSF4
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-Tnfrsf4 Antibody (V3S-0822-YC183) (CAT#: V3S-0822-YC183)
Target: Tnfrsf4
Host Species: Rat
Target Species: Mouse,
Application: FC,
