TNF superfamily member 12A

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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12A-TNFSF13. [provided by RefSeq, Oct 2010]
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Anti-TNFSF12A Neutralizing Antibody (V3S-1022-YC6032) (CAT#: V3S-1022-YC6032)

Target: TNFSF12A

Host Species: Human

Target Species: Human,

Application: ELISA,FC,IP,FuncS,IF,Neut,ICC,

For research use only, not directly for clinical use.

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