Salmonella enterica serovar typhi (S. typhi), the causative agent of typhoid fever, sickens an estimated 22 million people and claims over 0.2 million people's lives every year. This dynamic infectious cycle of S. Typhi is coordinated by many virulence factors, including typhoid toxin, Vi capsular polysaccharides, and Type III secretion system Salmonella Pathogenicity Island (SPI)-1 and SPI-2 effector toxins. Typhoid toxin is an exotoxin, which targets host cells located locally and remotely to benefit the pathogen primarily by altering host immune cell numbers and functions. Typhoid toxin is a heptameric A2B5 complex consisting of one each of two enzymatic "A" subunits CdtB and PltA and a glycan receptor-binding "B" homopentamer PltB.