| Description | This is a mouse monoclonal antibody that binds to human and macaque monkey EGFR. The affinity calculated from binding curve of the muEGFR-8 antibody was 1.43 nM for naked muEGFR-8 antibody. muEGFR-8 antibody also induced EGFR phosphorylation albeit the level of EGFR phosphorylation was lower than that of EGF. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human, Macaque |
| Affinity | KD = 1.43 nM |
| Isotype | Mouse IgG |
| Expression Species | HEK293F or CHO Cell line |
| Conjugation | Unconjugated, also available for Biotin, HRP, FITC and PE-labeled form. |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg, determined by LAL method |
| Purification | Purified with Protein A or G affinity chromatography |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | Cyt; WB |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | EGFR |
| Alternative Name | Epidermal Growth Factor Receptor; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; ERBB1; ERBB; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian) |
| Gene ID | 1956 |
| UniProt | P00533 |
| Related pathway | Apoptotic Pathways in Synovial Fibroblasts and Prolactin Signaling |
| Research Area | Signal Pathway |
| Related Disease | Inflammatory Skin And Bowel Disease, Neonatal, 2 and Lung Cancer |
