| Description | This product is a human neutralizing antibody binding to HIV-1 gp41. The kinetics of this antibody against HIV-1 gp41 peptide was measured by BLI and the Kd value is 9.4 nM. It has potent neutralizing ability and broad neutralizing breadth against multiple HIV viruses. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | HIV-1 |
| Epitope | Residues 656 to 683, NEQELLELDKWASLWNWFDITNWLWYIR. |
| Neutralization Mechanism | It binds to MPER of HIV-1 gp41. |
| IC50 | 25 μg/mL |
| Affinity | KD = 9.4 nM |
| Isotype | IgG |
| Expression Species | HEK293F or CHO cell |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; BLI; FC; Neut |
| Application Notes | Neutralization assay (Neut): The IC₅₀ value of this antibody against HIV-1 is 25 μg/mL. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HIV-1 gp41 |
| Alternative Name | Human immunodeficiency virus type 1 glycoprotein 41; HIV-1; gp41 |
| Research Area | Infectious Disease |
| Related Disease | Acquired Immune Deficiency Syndrome |
Figure 1 Binding ability of 10E8v4 to gp41 peptide measured by BLI.
10E8v4 antibody has potent affinity against gp41 peptide.
Figure 1 Binding ability of 10E8v4 to gp41 peptide measured by BLI.
