| Description | This is a human antibody with a strong affinity for HIV-1 gp41. VRC46.01 effectively neutralized the full clade B MPER chimera, although it did not have the same effect on the original HIV-2 virus. While VRC46.01's effectiveness was somewhat limited, it still showed activity against 30% of viruses from different subtypes, with a median IC₅₀ of 11 mg/mL. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human immunodeficiency virus type 1 (HIV1) |
| Epitope | AA 665-677, AA 678-682 |
| IC50 | 11 μg/mL |
| Isotype | Human IgG3 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HIV-1 gp41 |
| Alternative Name | HIV-1 ENV; MPER peptides; ENV; HIV-1; gp41; glycoprotein; gp; envelope |
| Research Area | Microbiology |
