Anti-HTRA1 (aa 224-248) Neutralizing Antibody (V3S-0522-YC2275) (CAT#: V3S-0522-YC2275)

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Description This product is a monoclonal antibody derived from Human (Homo sapiens), which can specifically recognize HtrA serine peptidase 1. The antibody is expressed with mammalian cell transient expression system, serum-free and purified by affinity chromatography. The purity and integrity are tested via SDS-PAGE and SEC-HPLC analysis. Given an antigen, additional QC measures are also desired such as affinity testing and binding validation.
Specifically, the antibody is provided in multiple formats for in vivo and in vitro assays. The Invivo version features greater than 95% purity, ultra-low endotoxin levels (<1 EU/mg or 0.1 EU/mg), and is preservative, stabilizer, and carrier protein-free.
Clonality Monoclonal
Host Species Human
Target Species Human, Mouse
Epitope The epitope that includes residues N224 and K248, which are located on Loop B and Loop C.
Affinity KD = 4.6 nM, determined by surface plasmon resonance.
Isotype IgG1


Expression Species HEK293F or CHO
Conjugation None
Purity >95%, determined by SDS-PAGE and/or SEC-HPLC
Endotoxin <1 EU/mg, determined by LAL method
Purification Protein A affinity purified
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4⁰C within a week. For longer storage, aliquot and store at -20⁰C.


Application ELISA; Inhib
Application Notes The antibody is recommended for detection of HTRA1 by ELISA, Inhib assays.


ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol


Target HTRA1
Alternative Name HtrA Serine Peptidase 1; High-Temperature Requirement A Serine Peptidase 1; Protease, Serine, 11 (IGF Binding); PRSS11; HtrA; L56; Serine Protease HTRA1; Serine Protease 11; IGFBP5-Protease
Gene ID 5654
UniProt Q92743
Research Area Metabolism; Cell Biology
For research use only, not directly for clinical use.
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