Name: ZIKV E Specific Neutra™ Antibody (V3S-0923-XY60), Human IgG
SKU: V3S-0923-XY60
Rating: 5 (1 reviews)

Description	ZIKV-195 is a potently human neutralizing antibody, which specifically recognizes ZIKV E protein. The potent neutralizing antibody ZIKV-195 broadly inhibits ZIKV strains and has therapeutic potential against ZIKV infection. This product has been detected by Enzyme-linked immunosorbent assay, Flow cytometry and Neutralization assay.
Clonality	Monoclonal
Host Species	Human
Target Species	ZIKV
Cross Reactivity	African (Dakar 41525 and MR 766), Asian (H/PF/2013 and Malaysia P6740), American (Paraiba 2015)
Epitope	ZIKV-195 binds to both E protomers forming dimers within one icosahedral asymmetric unit.
Neutralization Mechanism	ZIKV-195 binds to both E protomers forming dimers, thereby stabilizing the E dimers on the mature ZIKV particle and possibly preventing formation of fusogenic trimers.
IC₅₀	77-600 ng/mL
Isotype	Human IgG

Expression Species	HEK293F or CHO cell line
Conjugation	Unconjugated
Purity	>95%
Endotoxin	<1 EU/mg
Form	Liquid
Purification	Protein A purified
Sterility	0.2 μM filtered
Formulation	PBS, pH 7.4
Preservation	No preservatives
Stabilizer	No stabilizers
Storage	Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.

Application	ELISA; FC; Neut
Application Notes	Neutralization assay (Neut): Serial dilutions of mAbs were incubated with ∼100 FFU of different ZIKV strains for 1 h at 37°C.

ELISA	Enzyme-Linked Immunosorbent Assay Protocol
WB	Western Blot Protocol
FC	Flow Cytometry Protocol

Target	ZIKV E
Alternative Name	Zika virus envelope protein
Research Area	Infectious Disease
Related Disease	Severe neurological diseases

ZIKV E Specific Neutra™ Antibody (V3S-0923-XY60), Human IgG (CAT#: V3S-0923-XY60)