ZIKV-195 is a potently human neutralizing antibody, which specifically recognizes ZIKV E protein. The potent neutralizing antibody ZIKV-195 broadly inhibits ZIKV strains and has therapeutic potential against ZIKV infection. This product has been detected by Enzyme-linked immunosorbent assay, Flow cytometry and Neutralization assay.
African (Dakar 41525 and MR 766), Asian (H/PF/2013 and Malaysia P6740), American (Paraiba 2015)
ZIKV-195 binds to both E protomers forming dimers within one icosahedral asymmetric unit.
ZIKV-195 binds to both E protomers forming dimers, thereby stabilizing the E dimers on the mature ZIKV particle and possibly preventing formation of fusogenic trimers.
HEK293F or CHO cell line
Protein A purified
0.2 μM filtered
PBS, pH 7.4
Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
ELISA; FC; Neut
Neutralization assay (Neut): Serial dilutions of mAbs were incubated with ∼100 FFU of different ZIKV strains for 1 h at 37°C.