| Description |
ZIKV-195 is a potently human neutralizing antibody, which specifically recognizes ZIKV E protein. The potent neutralizing antibody ZIKV-195 broadly inhibits ZIKV strains and has therapeutic potential against ZIKV infection. This product has been detected by Enzyme-linked immunosorbent assay, Flow cytometry and Neutralization assay. |
| Clonality |
Monoclonal |
| Host Species |
Human |
| Target Species |
ZIKV |
| Cross Reactivity |
African (Dakar 41525 and MR 766), Asian (H/PF/2013 and Malaysia P6740), American (Paraiba 2015) |
| Epitope |
ZIKV-195 binds to both E protomers forming dimers within one icosahedral asymmetric unit. |
| Neutralization Mechanism |
ZIKV-195 binds to both E protomers forming dimers, thereby stabilizing the E dimers on the mature ZIKV particle and possibly preventing formation of fusogenic trimers. |
| IC50 |
77-600 ng/mL |
| Isotype |
Human IgG |
