| Description | This is a mouse IgG1 monoclonal antibody known as 21F12, which exhibits a strong affinity for the dense core of plaques in AD sections. The antibody specifically targets the epitope within residues Aβ 33-42. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human |
| Epitope | Amino acids 33-42 |
| Isotype | Mouse IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein G affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | IF |
| Application Notes | IF: 1-2 µg/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | APP |
| Alternative Name | Amyloid Beta Precursor Protein; Amyloid Beta (A4) Precursor Protein; Alzheimer Disease Amyloid Protein; Cerebral Vascular Amyloid Peptide; Amyloid Precursor Protein; Peptidase Nexin-II; Protease Nexin-II; PreA4; PN-II; ABPP; APPI; CVAP; AD1; Beta-Amyloid Precursor Protein |
| Gene ID | 351 |
| UniProt | P05067 |
| Related pathway | MyD88 dependent cascade initiated on endosome and GPCR downstream signalling |
| Research Area | Signal Pathway |
| Related Disease | Alzheimer's disease |
