CLEC2D Specific Neutra™ Antibody Products

Product list

C-type lectin domain family 2 member D (CLEC2D) is known as LLT1. As a member of the natural killer cell receptor C-type lectin family, CLEC2D is a single-pass type II membrane protein located in the endoplasmic reticulum and cell membrane. CLEC2D is ubiquitously expressed in many tissues, particularly high in the hematopoietic cells of the whole blood.

Its Gene ID: 29121, UniProtKB ID: Q9UHP7, and OMIM ID: 605659.

The Functions of CLEC2D-CD161 Interaction

A ligand of CLEC2D is CD161 expressed on natural killer cells and T cells. The interaction of CLEC2D-CD161 plays an important role in the immune regulation. The expression profiles of CLEC2D and CD161 are shown here.

Transduces inhibitory or costimulatory signals in the regulation of effector and memory T cells through the expression of CLEC2D on APCs such as dendritic cells (DC).
Inhibits the activation of immune cells and the NK cell-mediated lysis of tumor cells overexpressing CLEC2D.
Downregulates the release of cytokines and chemokines such as IFN-γ and CXC chemokines.

Fig.1 CLEC2D (LLT1) and CD161 expression profile.¹

Treatment Strategy for CLEC2D-CD161 Axis

The CLEC2D-CD161 axis plays a key role in the immune evasion of tumor cells against T lymphocytes and NK cells. As a novel pathway for immunotherapeutic intervention, both CLEC2D and CD161 are potential targets for the treatment of a broad range of cancers, such as breast cancer, melanoma, and diffuse glioma.

The expression of CLEC2D/CD161 may serve as a good biomarker for the prognosis after treatment of autoimmune diseases, infectious diseases, and cancers.
Monoclonal antibodies blocking the CLEC2D-CD161 pathway could synergize with the anti-PD-1/PD-L1 treatment for oncology immunotherapies.
Agonist antibodies of the CLEC2D-CD161 axis may re-balance the overactive immune system.

Creative Biolabs offers various anti-CLEC2D antibodies for immunoassay applications for research in autoimmune disease and cancer immunotherapy. These antibodies could be used to detect the CLEC2D-expressing levels, characterize CLEC2D-expressing cells, and explore the functions of CLEC2D.

Fig.2 Human CLEC2D protein was detected by anti-CLEC2D antibody (V3S-0622-YC1409) in ELISA.

Fig.3 Daudi cells were stained with anti-CLEC2D antibody (V3S-0622-YC5705) in flow cytometry.

Daudi cells were stained with anti-CLEC2D antibody (V3S-0622-YC5705) in flow cytometry. Fig.4 Anti-human CLEC2D Antibody (V3S-0622-YC5705) detected the human CLEC2D protein in WB.