F11 Specific Neutra™ Antibody Products
Product listCoagulation factor XI (F11) is an important component of the blood coagulation cascade. It is also known as FXI. As a secretory protein, F11 is overexpressed in normal tissues such as the liver, serum, plasma, and pancreas. F11 is associated with Factor Xi Deficiency and Thrombocytopenia diseases.
Its Gene ID: 2160 UniProtKB ID: P03951, and OMIM ID: 264900.
Effects of Targeting F11 in Thrombosis
The strategy targeting F11 has several positive responses in the treatment of thrombosis. The preclinical evidence is shown here.
Fig.1 Preclinical evidence for the potential impact of targeting F11.1
Treatment Strategies Associated with F11
F11 inhibitors could safely decrease the thrombus size, produce antithrombotic activity, and reduce ischemic events. Therefore, compounds targeting F11 have become promising approaches to prevent and treat thrombosis.
- Antisense oligonucleotides (ASOs) synthesize proteins intracellularly to block F11 with longer half-life times.
- Anti-F11 antagonist monoclonal antibodies have been used in studies for the prevention of thrombosis.
- Small peptidomimetic molecules, delivered orally, have a short half-life in company with renal clearance.
- Natural inhibitors may have a slow on/offset and a relatively high risk.
Fig.2 Kinds of F11 inhibitors and their targeting sites.2
Creative Biolabs offers high-quality anti-F11 antibodies to be used in cardiovascular immunoassays and functional assays. All these antibodies went through strict control to validate their purity, affinity, and specificity with commercial F11 antigens.
Fig.3 The human F11 protein was detected by anti-F11 antibody (V3S-0622-YC1556) in ELISA.
Fig.4 The SDS-PAGE analysis of purified anti-F11 antibody (V3S-0622-YC1556).
Fig.5 The SEC-HPLC analysis of anti-F11 antibody (V3S-0622-YC1556).
REFERENCES
- Wichaiyo, Surasak, et al. "Determination of the potential clinical benefits of small molecule factor XIa inhibitors in arterial thrombosis." ACS Pharmacology & Translational Science 6.7 (2023): 970-981.
- Poenou, Geraldine, et al. "Factor XI inhibition for the prevention of venous thromboembolism: an update on current evidence and future perspectives." Vascular health and risk management (2022): 359-373.
