MS4A1, also known as CD20, is a non-glycosylated protein of 33-37 kDa, commonly recognized as the universal B-cell marker. Expression for MS4A1 initiates in the late-stage pre-B lymphocytes and ceases in plasmablasts or plasma cells. Studies about its functionality have affirmed that MS4A1 is essential for effective B-cell BCR signal transduction. Its activation is associated with various B cell surface factors and plays a critical role in B cell activation, proliferation, and differentiation.
Its Gene ID: 931, UniProtKB ID: P11836, and OMIM ID: 112210.
Fig.1 MS4A1 and related signaling.1
MS4A1 serves as the universal B-cell marker, but its precise biological function is yet to be fully elucidated. Research reveals that MS4A1 interacts with multiple surface proteins, including B-cell receptors, CD53, CD81, and CD82, activating functional BCR signal pathways or other downstream signals. MS4A1 is considered one of the key signaling molecules necessary for T-dependent antigen reactions and T-independent humoral immune processes, as consistent with data obtained from MS4A1 mouse models.
In malignant B-cell tumors, MS4A1 exhibits variations in expression levels according to different tumor types. MS4A1 is considered as a potential therapeutic target for intervention in malignant B-cell tumors. Targeted antibody drugs have indeed been developed that demonstrate efficacy in B-cell leukemia and lymphomas, effectively enhancing overall survival rates and progression-free survival rates.
Fig.2 Therapeutic effects of MS4A1.2
With the advancing research into the pathology and immunology principles of MS, its molecular background is gradually shifting from T-cell mediated to B-cell mediated. Therefore, anti-MS4A1 antibody intervention is believed to be a prospective strategy for extended targeted intervention in MS.
Fig.3 Therapeutic effects of MS4A1 in MS.2
Creative Biolabs offers a wide range of MS4A1-related products alongside one-stop comprehensive antibody services, aiding in exploring the boundless potential of MS4A1. Please feel free to explore the full potential of our neutralizing antibody platform and recombinant antibody platform.
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2216) (CAT#: V3S-0622-YC2216)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: IF,IP,Neut,FuncS,ELISA,FC,WB,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2218) (CAT#: V3S-0622-YC2218)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FC,IP,ELISA,Neut,FuncS,IF,IHC,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2214) (CAT#: V3S-0622-YC2214)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2964) (CAT#: V3S-0622-YC2964)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2965) (CAT#: V3S-0622-YC2965)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2966) (CAT#: V3S-0622-YC2966)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2967) (CAT#: V3S-0622-YC2967)
Target: MS4A1
Host Species: Goat
Target Species: Human,
Application: ELISA,WB,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2968) (CAT#: V3S-0622-YC2968)
Target: MS4A1
Host Species: Mouse
Target Species: Dog,
Application: ELISA,FC,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2969) (CAT#: V3S-0622-YC2969)
Target: MS4A1
Host Species: Mouse
Target Species: Dog,
Application: ELISA,
Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2970) (CAT#: V3S-0622-YC2970)
Target: MS4A1
Host Species: Mouse
Target Species: Dog,
Application: ELISA,FC,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4922) (CAT#: V3S-0622-YC4922)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4923) (CAT#: V3S-0622-YC4923)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4924) (CAT#: V3S-0622-YC4924)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4926) (CAT#: V3S-0622-YC4926)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4927) (CAT#: V3S-0622-YC4927)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4928) (CAT#: V3S-0622-YC4928)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4929) (CAT#: V3S-0622-YC4929)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4930) (CAT#: V3S-0622-YC4930)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4931) (CAT#: V3S-0622-YC4931)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4932) (CAT#: V3S-0622-YC4932)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4933) (CAT#: V3S-0622-YC4933)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4934) (CAT#: V3S-0622-YC4934)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4935) (CAT#: V3S-0622-YC4935)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4936) (CAT#: V3S-0622-YC4936)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4937) (CAT#: V3S-0622-YC4937)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4938) (CAT#: V3S-0622-YC4938)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4940) (CAT#: V3S-0622-YC4940)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4941) (CAT#: V3S-0622-YC4941)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4942) (CAT#: V3S-0622-YC4942)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4943) (CAT#: V3S-0622-YC4943)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4944) (CAT#: V3S-0622-YC4944)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4945) (CAT#: V3S-0622-YC4945)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4946) (CAT#: V3S-0622-YC4946)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4947) (CAT#: V3S-0622-YC4947)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4949) (CAT#: V3S-0622-YC4949)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4950) (CAT#: V3S-0622-YC4950)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4951) (CAT#: V3S-0622-YC4951)
Target: MS4A1
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4952) (CAT#: V3S-0622-YC4952)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4953) (CAT#: V3S-0622-YC4953)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4954) (CAT#: V3S-0622-YC4954)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4955) (CAT#: V3S-0622-YC4955)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4956) (CAT#: V3S-0622-YC4956)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4957) (CAT#: V3S-0622-YC4957)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4958) (CAT#: V3S-0622-YC4958)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4959) (CAT#: V3S-0622-YC4959)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4960) (CAT#: V3S-0622-YC4960)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4961) (CAT#: V3S-0622-YC4961)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4962) (CAT#: V3S-0622-YC4962)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4963) (CAT#: V3S-0622-YC4963)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4964) (CAT#: V3S-0622-YC4964)
Target: MS4A1
Host Species: Human
Target Species: Human,
Application: FuncS,
