MS4A1 Specific Neutra™ Antibody Products

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MS4A1, also known as CD20, is a non-glycosylated protein of 33-37 kDa, commonly recognized as the universal B-cell marker. Expression for MS4A1 initiates in the late-stage pre-B lymphocytes and ceases in plasmablasts or plasma cells. Studies about its functionality have affirmed that MS4A1 is essential for effective B-cell BCR signal transduction. Its activation is associated with various B cell surface factors and plays a critical role in B cell activation, proliferation, and differentiation.

Its Gene ID: 931, UniProtKB ID: P11836, and OMIM ID: 112210.

Fig.1 MS4A1 and related signaling. (Pavlasova, et al., 2020)Fig.1 MS4A1 and related signaling.1

MS4A1 Biology

MS4A1 serves as the universal B-cell marker, but its precise biological function is yet to be fully elucidated. Research reveals that MS4A1 interacts with multiple surface proteins, including B-cell receptors, CD53, CD81, and CD82, activating functional BCR signal pathways or other downstream signals. MS4A1 is considered one of the key signaling molecules necessary for T-dependent antigen reactions and T-independent humoral immune processes, as consistent with data obtained from MS4A1 mouse models.

MS4A1 Pathology

  • MS4A1 in Cancer

In malignant B-cell tumors, MS4A1 exhibits variations in expression levels according to different tumor types. MS4A1 is considered as a potential therapeutic target for intervention in malignant B-cell tumors. Targeted antibody drugs have indeed been developed that demonstrate efficacy in B-cell leukemia and lymphomas, effectively enhancing overall survival rates and progression-free survival rates.

Fig.2 Therapeutic effects of MS4A1. (Pavlasova, et al., 2020)Fig.2 Therapeutic effects of MS4A1.2

  • MS4A1 in Multiple Sclerosis (MS)

With the advancing research into the pathology and immunology principles of MS, its molecular background is gradually shifting from T-cell mediated to B-cell mediated. Therefore, anti-MS4A1 antibody intervention is believed to be a prospective strategy for extended targeted intervention in MS.

Fig.3 Therapeutic effects of MS4A1 in MS. (Chmielewska, et al., 2023)Fig.3 Therapeutic effects of MS4A1 in MS.2

Creative Biolabs offers a wide range of MS4A1-related products alongside one-stop comprehensive antibody services, aiding in exploring the boundless potential of MS4A1. Please feel free to explore the full potential of our neutralizing antibody platform and recombinant antibody platform.

REFERENCES

  1. Pavlasova, Mraz, et al. "The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy." Haematologica 105.6 (2020): 1494-1506.
  2. Chmielewska, Szyndler, et al. " Targeting CD20 in multiple sclerosis — review of current treatment strategies." Polish Journal of Neurology and Neurosurgery 57.3 (2023): 235-242.
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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2216) (CAT#: V3S-0622-YC2216)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: IF,IP,Neut,FuncS,ELISA,FC,WB,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2218) (CAT#: V3S-0622-YC2218)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FC,IP,ELISA,Neut,FuncS,IF,IHC,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC383) (CAT#: V3S-0622-YC383)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: ELISA,IHC,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC384) (CAT#: V3S-0622-YC384)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2214) (CAT#: V3S-0622-YC2214)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2215) (CAT#: V3S-0622-YC2215)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: ELISA,IP,FC,FuncS,IF,Neut,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2217) (CAT#: V3S-0622-YC2217)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: Neut,ELISA,IF,IP,FuncS,FC,ICC,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC2219) (CAT#: V3S-0622-YC2219)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: IP,IF,FuncS,FC,Neut,ELISA,ICC,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2964) (CAT#: V3S-0622-YC2964)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2965) (CAT#: V3S-0622-YC2965)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2966) (CAT#: V3S-0622-YC2966)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: ELISA,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2967) (CAT#: V3S-0622-YC2967)

Target: MS4A1

Host Species: Goat

Target Species: Human,

Application: ELISA,WB,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2968) (CAT#: V3S-0622-YC2968)

Target: MS4A1

Host Species: Mouse

Target Species: Dog,

Application: ELISA,FC,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2969) (CAT#: V3S-0622-YC2969)

Target: MS4A1

Host Species: Mouse

Target Species: Dog,

Application: ELISA,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC2970) (CAT#: V3S-0622-YC2970)

Target: MS4A1

Host Species: Mouse

Target Species: Dog,

Application: ELISA,FC,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC3715) (CAT#: V3S-0622-YC3715)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,

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Recombinant Anti-MS4A1 Antibody (V3S-0622-YC3716) (CAT#: V3S-0622-YC3716)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: ELISA,IHC,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4922) (CAT#: V3S-0622-YC4922)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4923) (CAT#: V3S-0622-YC4923)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4924) (CAT#: V3S-0622-YC4924)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4925) (CAT#: V3S-0622-YC4925)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4926) (CAT#: V3S-0622-YC4926)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4927) (CAT#: V3S-0622-YC4927)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4928) (CAT#: V3S-0622-YC4928)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4929) (CAT#: V3S-0622-YC4929)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4930) (CAT#: V3S-0622-YC4930)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4931) (CAT#: V3S-0622-YC4931)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4932) (CAT#: V3S-0622-YC4932)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4933) (CAT#: V3S-0622-YC4933)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4934) (CAT#: V3S-0622-YC4934)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4935) (CAT#: V3S-0622-YC4935)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4936) (CAT#: V3S-0622-YC4936)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4937) (CAT#: V3S-0622-YC4937)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4938) (CAT#: V3S-0622-YC4938)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4939) (CAT#: V3S-0622-YC4939)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4940) (CAT#: V3S-0622-YC4940)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4941) (CAT#: V3S-0622-YC4941)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4942) (CAT#: V3S-0622-YC4942)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4943) (CAT#: V3S-0622-YC4943)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4944) (CAT#: V3S-0622-YC4944)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4945) (CAT#: V3S-0622-YC4945)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4946) (CAT#: V3S-0622-YC4946)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4947) (CAT#: V3S-0622-YC4947)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4948) (CAT#: V3S-0622-YC4948)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

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Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4949) (CAT#: V3S-0622-YC4949)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

Inquiry

Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4950) (CAT#: V3S-0622-YC4950)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

Inquiry

Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4951) (CAT#: V3S-0622-YC4951)

Target: MS4A1

Host Species: Mouse

Target Species: Human,

Application: FuncS,

Inquiry

Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4952) (CAT#: V3S-0622-YC4952)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

Inquiry

Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4953) (CAT#: V3S-0622-YC4953)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

Inquiry

Anti-MS4A1 Neutralizing Antibody (V3S-0622-YC4954) (CAT#: V3S-0622-YC4954)

Target: MS4A1

Host Species: Human

Target Species: Human,

Application: FuncS,

For research use only, not directly for clinical use.


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