NOTCH2 Specific Neutra™ Antibody Products

Notch Receptor 2 (Notch2), also known as Neurogenic Locus Notch Homolog Protein 2 or HN2, is a critical member of the Notch family. Notch2 is a typical transmembrane protein. Similar to other members of the transmembrane protein family, Notch2 includes an extracellular domain and an intracellular domain. In general, Notch 2 is critical for maintaining neural progenitor cell proliferation. However, Notch2 expression was shown to be upregulated in glioblastoma. Furthermore, Notch2 also promotes tumor cell proliferation.

Its Gene ID: 4853, UniProtKB ID: Q04721, and OMIM ID: 600275.

Function

Notch2 is essential for the development and function of many tissues throughout the body. It is reported that the Notch2 signaling pathway is closely related to the development of the heart, liver, kidney, and bones during the embryonic period. In addition, Notch2 signaling is also involved in various life activities, such as neural development, immune system regulation, tissue repair, and bone remodeling.

Fig.1 Structures of NOTCH1 and NOTCH2 receptors.^1,3

Notch2 Signaling Pathways

In general, the Notch2 signaling pathway is an evolutionarily highly conserved signaling system found in most animals. Notch2 serves as a crucial regulator in multiple developmental processes by controlling cell fate. The Notch2 signaling pathway is an essential hub for intercellular communication and is involved in the gene regulation of cell differentiation processes in embryonic and adult development.

Related Diseases

Evidence reveals that aberrant Notch2 signaling may contribute to a variety of diseases, including multiple sclerosis, acute lymphoblastic leukemia, and cerebral arteriopathy. Notch2 signaling has also been reported to be closely associated with the development of many hematological malignancies, including multiple myeloma as well as B-cell and T-cell acute lymphoblastic leukemia. In addition, abnormalities in Notch2 may trigger various solid tumors, including colon cancer, cervical cancer, small cell lung cancer, and pancreatic cancer.

Fig.2 Contact dependent Notch signaling between cells.^2,3

Therapies Targeting Notch2

The blocking potential of Notch2 in various tumors has been reported. Therefore, targeting Notch2 may provide new ideas for cancer treatment. It has been reported that administration of specific anti-Notch2 neutralizing antibodies effectively protects bone microvasculature from methotrexate-induced dilation and regression.

Anti-Notch 2 Antibody Products

At Creative Biolabs, we offer Notch2 monoclonal antibodies and neutralizing antibodies for research use only. Our diverse antibody products are suitable for a variety of research purposes, including receptor-ligand interaction blocking, immunohistochemistry, ELISA, flow cytometry, western blotting, immunofluorescence, and immunoprecipitation. Our Notch2 antibodies are available for humans, rats, and mice. Our professional antibody research and development team is at your service, please contact us in time for professional help.

REFERENCES

1. Deshotels, Leigh, Firas M. Safa, and Nakhle S. Saba. "NOTCH signaling in mantle cell lymphoma: Biological and clinical implications." International Journal of Molecular Sciences 24.12 (2023): 10280.
2. Gallenstein, Nadia, et al. "Notch signaling in acute inflammation and sepsis." International Journal of Molecular Sciences 24.4 (2023): 3458.
3. Distributed under Open Access license CC BY 4.0, without modification.