Plasmodium falciparum circumsporozoite protein

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Plasmodium falciparum (Pf) is the etiological agent of malaria, a vector-borne infectious disease with an estimated disease burden of 229 million cases and 409,000 deaths in 2019 alone. The Pf circumsporozoite protein (PfCSP), comprised of an N-terminus, a central repeating tetrapeptide region, and a C-terminus, is the most abundant protein on the SPZ surface and is required for motility and hepatocyte invasion. Repeat antigens such as PfCSP can assume divergent structures, which confound both recognition and maturation of the humoral immune response. Nevertheless, PfCSP is currently the best target for neutralizing antibodies, and the most advanced malaria vaccine-RTS,S-presents a truncated portion of the PfCSP repeat containing only NANP and C-terminal regions.

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Anti-PfCSP Neutralizing Antibody (V3S-0522-YC843) (CAT#: V3S-0522-YC843)

Target: PfCSP

Host Species: Human

Target Species: Plasmodium falciparum,

Application: ELISA,IF,Inhib,