Description | The antibody 2-15 is a human mAb specific for SARS-CoV-2 Spike S1 protein. The antibody neutralizes authentic SARS-CoV-2 "live" virus with an IC50 of 0.0007 μg/mL. The crystal structure of the antibody complexed with SARS-CoV-2 RBD revealed the antibody to use similar heavy- and light-chain regions to recognize the RBM. |
Clonality | Monoclonal |
Host Species | Human |
Target Species | SARS-CoV-2 |
Epitope | The epitope is in the receptor-binding motif (RBM) that interacts directly with ACE2. |
Isotype | IgG1 |
Expression Species | HEK293F or CHO cell line |
Conjugation | Unconjugated |
Purity | >95% |
Endotoxin | <1 EU/mg |
Form | Liquid |
Purification | Protein A purified |
Sterility | 0.2 μM filtered |
Formulation | PBS, pH 7.4 |
Preservation | No preservatives |
Stabilizer | No stabilizers |
Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
Application | ELISA, Neut |
Application Notes | The IC50 value was tested by pseudovirus neutralization assays. The antibody 2-15 neutralizes authentic SARS-CoV-2 "live" virus with an IC50 of 0.0007 μg/mL. |
ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
WB | Western Blot Protocol |
FC | Western Blot Protocol |
Target | SARS-CoV-2 |
Alternative Name | Severe acute respiratory syndrome coronavirus 2 |
Research Area | Coronavirus Disease 2019 |
Related Disease | Coronavirus Disease 2019 |