| Description | This product is a human antibody that specifically targets human SNCA. It attaches to α-syn residues 1-10. It exhibits a remarkable preference for aggregated forms of α-syn, displaying an apparent affinity that is at least 800 times higher for fibrillar α-syn compared to monomeric recombinant α-syn. Furthermore, it demonstrates a strong affinity for human PD brain tissue, effectively distinguishing between monomers and oligomeric/fibrillar forms of α-syn due to its high avidity for aggregates. This avidity is a result of its weak monovalent affinity and rapid binding kinetics. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Epitope | AA 1-10 |
| Affinity | KD = 120 pM |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; FuncS; IHC; DB |
| Application Notes | IHC: 2-8 μg/mL Dot blot: 1.25 μg/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
