IL4R Specific Neutra™ Antibody Products
Product listInterleukin 4 Receptor (IL4R), also known as CD124, is a crucial member of the cytokine receptor family. The IL4R has been proven to regulate IgE production by binding to IL4. Furthermore, IL4R plays a crucial role in IL4-mediated cell proliferation. In addition, accumulating evidence suggests that IL4R-mediated signaling pathways are involved in the regulation of the immune system. Anti-IL4R neutralizing or blocking antibodies are helpful for studies on IL-4 regulation.
Its Gene ID: 3566, UniProtKB ID: P24394, and OMIM ID: 147781.
Fig.1 Structure of IL4R.1
IL4/IL4R Signaling
IL4R is expressed on a variety of cells, including liver cells, muscle cells, and fibroblasts. The distribution of IL4R contributes to the broad function of the IIL4/IIL4R signaling pathway. Phosphorylation of IL4Ra (IL4R, alpha) also plays a role in the function of IL4R. Modified IL4Ra creates connection sites for multiple signaling pathways. It is worth noting that activation of IL4R may also be involved in the activation of other signaling pathways, such as the MAPK pathway and PI3K pathway.
Fig.2 Cellular distribution of IL4R.2
Related Diseases
The IL4/IL4R signaling axis is closely associated with the invasion and proliferation of epithelial cancer cells. Furthermore, IL4/IL4R has been shown to induce glucose metabolism in breast cancer cells. Currently, IL4R provides a new direction for the therapy of diverse metastatic tumors. In addition to its tumor-promoting functions, IL4/IL4R signaling has been associated with many multiple diseases, including allergy, atopic dermatitis, and asthma.
Blocking IL4R Activity
Various antibodies can inhibit IL4/IL4R binding, providing new strategies for blocking the IL4 signaling pathway. With decades of antibody research experience, we are confident in providing high-quality antibody products to global customers. At Creative Biolabs, the blocking activity of the IL4R neutralizing antibodies is rigorously verified in specific cell lines. You can select suitable IL4R antibodies that meet your requirements from our collection of antibodies. If you are interested in our antibodies directed against IL4R, please contact us with a specific request.
REFERENCES
- Iwaszko, Milena, Sylwia Biały, and Katarzyna Bogunia-Kubik. "Significance of interleukin (IL)-4 and IL-13 in inflammatory arthritis." Cells 10.11 (2021): 3000..
- Junttila, Ilkka S. "Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes." Frontiers in immunology 9 (2018): 338745.
