| Description | This product is a monkey neutralizing antibody clone VD20.5A4, which targeting the glycoprotein 120 of HIV-1. VD20.5A4 displayed neutralizing activity against the virus and it is one of the most potent neutralizing antibody against HIV-1. |
| Clonality | Monoclonal |
| Host Species | Monkey |
| Target Species | HIV-1 |
| Immunogen | Variants of NFL HIV-1 Env trimers derived from the tier 2 clade C 16055 strain |
| Epitope | It recognizes a hypervariable region within V2 (residues 184-186). |
| Isotype | Monkey IgG |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; Neut |
| Application Notes | ELISA: After incubation with blocking buffer, the mAb was added and incubated for 1 hour at 37°C. Neutralization assay (Neut): Serial dilutions of the mAb was performed and the neutralization dose-response curves were fit by non-linear regression. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HIV-1 gp120 |
| Alternative Name | Human immunodeficiencyvirus-1 glycoprotein 120 |
| Research Area | Infectious Disease |
| Related Disease | Acquired Immune Deficiency Syndrome |
