| Description | This human anti-HIV-1 neutrilzing antibody (clone 438-B11) specifically recognizes HIV-1 gp120 N332/V3-glycan supersite. It could neutralize HIV-1 with moderate breadth. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | HIV-1 |
| Immunogen | HIV-1 subtype B |
| Epitope | N332/V3-glycan supersite on HIV-1 gp120 |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| Application Notes | The binding activities of this mAb to HIV-1 were examined by ELISA. And ELISA was also used to probe the 438-B11 epitopes on the HIV-1 gp120. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HIV-1 gp120 |
| Alternative Name | HIV-1 gp120 V3; Human immunodeficiency virus-1 gp120 V3; human immunodeficiency virus; HIV; Retroviridae; HIV-1 gp120; Human immunodeficiency virus-1 gp120 |
| Research Area | Microbiology; Immunology |
| Related Disease | AIDS |
